Endocytoscopy can be used to assess histological healing in ulcerative colitis

Yoshihiro Nakazato; Makoto Naganuma; Shinya Sugimoto; Rieko Bessho; Mari Arai; Hiroki Kiyohara; Keiko Ono; Kosaku Nanki; Makoto Mutaguchi; Shinta Mizuno; Taku Kobayashi; Naoki Hosoe; Masayuki Shimoda; Takayuki Abe; Nagamu Inoue; Haruhiko Ogata; Yasushi Iwao; Takanori Kanai

doi:10.1055/s-0043-106556

Endocytoscopy can be used to assess histological healing in ulcerative colitis

Yoshihiro Nakazato, Makoto Naganuma, Shinya Sugimoto, Rieko Bessho, Mari Arai, Hiroki Kiyohara, Keiko Ono, Kosaku Nanki, Makoto Mutaguchi, Shinta Mizuno, Taku Kobayashi, Naoki Hosoe, Masayuki Shimoda, Takayuki Abe, Nagamu Inoue, Haruhiko Ogata, Yasushi Iwao, Takanori Kanai

Research output: Contribution to journal › Article › peer-review

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Abstract

Background and study aim Endocytoscopy (ECS) is used in the in vivo microscopic inspection of microstructural mucosal features and enables endoscopists to assess the histological severity of ulcerative colitis (UC). The aim of this study was to assess histological healing in UC patients by using ECS. Patients and methods A total of 64 patients in clinical and endoscopic remission who underwent ECS were selected. The correlation between the ECS score and Geboes score at the rectum was evaluated in patients with a Mayo endoscopic score (MES) of 0.The diagnostic accuracy of the ECS score for histological remission (Geboes score ≤2) was also assessed. Results The ECS score ranged from 0 to 5 in patients with endoscopic remission on conventional white-light images (MES of 0). The agreement between histological remission regarding the ECS score and the Geboes score had a κ value of 0.72, and the ECS score showed high accuracy for histological remission, with a sensitivity of 0.77, a specificity of 0.97, and a diagnostic accuracy of 0.86. Conclusion ECS can be used to assess histological healing in patients with UC without the need for biopsy specimens.

Original language	English
Pages (from-to)	560-563
Number of pages	4
Journal	Endoscopy
Volume	49
Issue number	6
DOIs	https://doi.org/10.1055/s-0043-106556
Publication status	Published - 2017 Jun 1

ASJC Scopus subject areas

Gastroenterology

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title = "Endocytoscopy can be used to assess histological healing in ulcerative colitis",

abstract = "Background and study aim Endocytoscopy (ECS) is used in the in vivo microscopic inspection of microstructural mucosal features and enables endoscopists to assess the histological severity of ulcerative colitis (UC). The aim of this study was to assess histological healing in UC patients by using ECS. Patients and methods A total of 64 patients in clinical and endoscopic remission who underwent ECS were selected. The correlation between the ECS score and Geboes score at the rectum was evaluated in patients with a Mayo endoscopic score (MES) of 0.The diagnostic accuracy of the ECS score for histological remission (Geboes score ≤2) was also assessed. Results The ECS score ranged from 0 to 5 in patients with endoscopic remission on conventional white-light images (MES of 0). The agreement between histological remission regarding the ECS score and the Geboes score had a κ value of 0.72, and the ECS score showed high accuracy for histological remission, with a sensitivity of 0.77, a specificity of 0.97, and a diagnostic accuracy of 0.86. Conclusion ECS can be used to assess histological healing in patients with UC without the need for biopsy specimens.",

author = "Yoshihiro Nakazato and Makoto Naganuma and Shinya Sugimoto and Rieko Bessho and Mari Arai and Hiroki Kiyohara and Keiko Ono and Kosaku Nanki and Makoto Mutaguchi and Shinta Mizuno and Taku Kobayashi and Naoki Hosoe and Masayuki Shimoda and Takayuki Abe and Nagamu Inoue and Haruhiko Ogata and Yasushi Iwao and Takanori Kanai",

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year = "2017",

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doi = "10.1055/s-0043-106556",

language = "English",

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T1 - Endocytoscopy can be used to assess histological healing in ulcerative colitis

AU - Nakazato, Yoshihiro

AU - Naganuma, Makoto

AU - Sugimoto, Shinya

AU - Bessho, Rieko

AU - Arai, Mari

AU - Kiyohara, Hiroki

AU - Ono, Keiko

AU - Nanki, Kosaku

AU - Mutaguchi, Makoto

AU - Mizuno, Shinta

AU - Kobayashi, Taku

AU - Hosoe, Naoki

AU - Shimoda, Masayuki

AU - Abe, Takayuki

AU - Inoue, Nagamu

AU - Ogata, Haruhiko

AU - Iwao, Yasushi

AU - Kanai, Takanori

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Background and study aim Endocytoscopy (ECS) is used in the in vivo microscopic inspection of microstructural mucosal features and enables endoscopists to assess the histological severity of ulcerative colitis (UC). The aim of this study was to assess histological healing in UC patients by using ECS. Patients and methods A total of 64 patients in clinical and endoscopic remission who underwent ECS were selected. The correlation between the ECS score and Geboes score at the rectum was evaluated in patients with a Mayo endoscopic score (MES) of 0.The diagnostic accuracy of the ECS score for histological remission (Geboes score ≤2) was also assessed. Results The ECS score ranged from 0 to 5 in patients with endoscopic remission on conventional white-light images (MES of 0). The agreement between histological remission regarding the ECS score and the Geboes score had a κ value of 0.72, and the ECS score showed high accuracy for histological remission, with a sensitivity of 0.77, a specificity of 0.97, and a diagnostic accuracy of 0.86. Conclusion ECS can be used to assess histological healing in patients with UC without the need for biopsy specimens.

AB - Background and study aim Endocytoscopy (ECS) is used in the in vivo microscopic inspection of microstructural mucosal features and enables endoscopists to assess the histological severity of ulcerative colitis (UC). The aim of this study was to assess histological healing in UC patients by using ECS. Patients and methods A total of 64 patients in clinical and endoscopic remission who underwent ECS were selected. The correlation between the ECS score and Geboes score at the rectum was evaluated in patients with a Mayo endoscopic score (MES) of 0.The diagnostic accuracy of the ECS score for histological remission (Geboes score ≤2) was also assessed. Results The ECS score ranged from 0 to 5 in patients with endoscopic remission on conventional white-light images (MES of 0). The agreement between histological remission regarding the ECS score and the Geboes score had a κ value of 0.72, and the ECS score showed high accuracy for histological remission, with a sensitivity of 0.77, a specificity of 0.97, and a diagnostic accuracy of 0.86. Conclusion ECS can be used to assess histological healing in patients with UC without the need for biopsy specimens.

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Endocytoscopy can be used to assess histological healing in ulcerative colitis

Abstract

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