Endoscopic diagnosis of cytomegalovirus gastritis after allogeneic hematopoietic stem cell transplantation

Yasuo Kakugawa, Masahiro Kami, Takahisa Matsuda, Yutaka Saito, Sung Won Kim, Takahiro Fukuda, Shin ichiro Mori, Tadakazu Shimoda, Ryuji Tanosaki, Daizo Saito

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


AIM: To clarify the endoscopic and clinical findings of cytomegalovirus (CMV) gastritis after allogeneic hema-topoietic stem cell transplantation (allo-SCT). METHODS: Between 1999 and 2005, 523 patients underwent allo-SCT at our hospital, and 115 of these patients with gastrointestinal symptoms underwent esophagogastroduodenoscopy. RESULTS: CMV gastritis was diagnosed pathologically in seven patients (1.3%) with the other 108 patients serving as controls. Six of the seven patients devel-oped positive CMV antigenemia, and five complained of abdominal pain. Development of abdominal pain preceded CMV antigenemia in four of the five patients. Endoscopic examination showed oozing (n = 2), erosion (n = 6), and redness (n = 5) in the seven patients with CMV gastritis, while the control patients showed oozing (n = 3), erosion (n = 24), and redness (n = 100). Ero-sion and oozing were more frequently documented in patients with CMV gastritis compared with the controls, and the differences were statistically significant (P = 0.0012 and 0.029, respectively). CMV inclusion bodies were documented in 12 of 14 biopsy specimens ob-tained from erosive lesions, while they were identified in 4 of 15 biopsy specimens obtained from lesions other than erosions (P = 0.0025). CONCLUSION: This study suggests that erosion and oozing, as well as abdominal pain, are useful indicators in the diagnosis of CMV gastritis following allo-SCT.

Original languageEnglish
Pages (from-to)2907-2912
Number of pages6
JournalWorld Journal of Gastroenterology
Issue number23
Publication statusPublished - 2010 Jun
Externally publishedYes


  • Cytomegalovirus antigenemia
  • Cytomegalovirus gastritis
  • Esophagogastroduodenoscopy
  • Graft-versus-host disease
  • Hematopoietic stem cell transplantation

ASJC Scopus subject areas

  • Gastroenterology


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