Endoscopic Findings of Esophagitis in Concurrent Chemo-radiotherapy for Lung Cancer

Hirokazu Watanabe, Saeko Hirota, Toshinori Soejima, Kenya Honda, Koichi Kono, Yoshio Hishikawa, Kayoko Obayasi, Yoshiki Takada

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


We performed esophageal endoscopy with concurrent chemo-radiotherapy for lung cancer in 19 patients. Endoscopical examination proved that seven patients (36.8 %) had esophageal erosion or coating (grade 2), four patients (21.1%) had ulcer or bleeding (grade 3) confined to the radiation field, and only one patient (5.3%) had severe symptoms (WHO grade 3). There was a discrepancy between patients' symptoms and endoscopical findings. Endoscopically proven esophagitis, that is, erosion or coating (grade 2), and ulcer or bleeding (grade 3 ), was more frequent in the daily low-dose chemotherapy group (5/5) than in the full dose chemotherapy group (5/14) (p < 0.05). One patient with grade 3 endoscopial damage showed less recovery ; in spite of three months medication. In concurrent radiochemotherapy in which the radiation field includes the esophagus, careful attention should be given to radiation esophagitis, which may be underestimated when asessed on the basis of subjective symptoms alone. Therefore, endoscopy is recommended even if patients have few complaints, and once the esophageal ulcer is proven (grade 3), it should be closely followed up using endoscopy.

Original languageEnglish
Pages (from-to)271-276
Number of pages6
JournalNippon Acta Radiologica
Issue number6
Publication statusPublished - 1998
Externally publishedYes


  • Chemotherapy
  • Esophagttis
  • Lung cancer
  • Radiotherapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology


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