Endoscopic therapy for gastroesophageal reflux disease

Hidekazu Suzuki, Eisuke Iwasaki, Toshifumi Hibi

Research output: Contribution to journalReview articlepeer-review


A variety of endoscopic techniques for the treatment of gastroesophageal reflux disease (GERD) have been developed as alternatives to PPI therapy or antireflux surgery. These techniques include the delivery of radiofrequency energy to the gastroesophageal junction, injection of agents into the lower esophageal sphincter zone, and suture plication of the proximal fundic folds. Each of these endoscopic techniques is designed to alter the anatomy or physiology of the gastroesophageal junction to decrease gastroesophageal reflux. However, only limited data are available on the mechanism of action of the various endoscopic techniques. Most studies of endoscopic therapy have only limited follow-up information, and safety issues remain unresolved. Further sham-controlled clinical trials will be required for endoscopic device and technique.

Original languageEnglish
Pages (from-to)895-899
Number of pages5
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number5
Publication statusPublished - 2007 May

ASJC Scopus subject areas

  • General Medicine


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