TY - GEN
T1 - Engineering cost function for optimizing coherent control between processes with different nonlinearities
AU - Chen, J.
AU - Nabekawa, Y.
AU - Midorikawa, K.
AU - Kawano, H.
AU - Mizuno, H.
AU - Miyawaki, A.
AU - Tanabe, T.
AU - Kannari, F.
N1 - Publisher Copyright:
© 2004 Optical Society of America.
PY - 2004
Y1 - 2004
N2 - Multiphoton fluorescence microscopy offers ability of imaging thick samples with enhanced longitudinal resolution, but suffers from issues of photobleaching and phototoxicity. It has been known that three-photon absorption of DNA is one of the causes of phototoxicity. Here, we apply coherent control to enhance the contrast between the two-photon absorption of fluorescent label and the three-photon absorption of biomaterial with engineered cost function, leading to effectively reduced three-photon absorption without loss of valuable two-photon fluorescence.
AB - Multiphoton fluorescence microscopy offers ability of imaging thick samples with enhanced longitudinal resolution, but suffers from issues of photobleaching and phototoxicity. It has been known that three-photon absorption of DNA is one of the causes of phototoxicity. Here, we apply coherent control to enhance the contrast between the two-photon absorption of fluorescent label and the three-photon absorption of biomaterial with engineered cost function, leading to effectively reduced three-photon absorption without loss of valuable two-photon fluorescence.
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M3 - Conference contribution
AN - SCOPUS:85136083302
T3 - Optics InfoBase Conference Papers
BT - International Conference on Ultrafast Phenomena, UP 2004
PB - Optica Publishing Group (formerly OSA)
T2 - International Conference on Ultrafast Phenomena, UP 2004
Y2 - 25 July 2004 through 30 July 2004
ER -