Enhanced photodynamic effect by the assistance of nanosecond-pulsed-laser- induced stress wave

Mitsuhiro Terakawa; Shunichi Sato; Satoko Kawauchi; Hiroshi Ashida; Minoru Obara

doi:10.1143/JJAP.43.L877

Enhanced photodynamic effect by the assistance of nanosecond-pulsed-laser- induced stress wave

Mitsuhiro Terakawa, Shunichi Sato, Satoko Kawauchi, Hiroshi Ashida, Minoru Obara

Department of Electronics and Electrical Engineering

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We demonstrated that phototoxicity was enhanced by applying a single nanosecond-pulsed-laser-induced stress wave (LISW) to cultured cells before photodynamic treatment. Observation with a confocal laser scanning microscope showed that the enhanced phototoxicity is attributable to the larger cellular uptake of a photosensitizer due to the effect of LISW. It was also confirmed that the application of LISW alone did not reduce the cell viability.

Original language	English
Pages (from-to)	L877-L878
Journal	Japanese Journal of Applied Physics, Part 2: Letters
Volume	43
Issue number	7 A
DOIs	https://doi.org/10.1143/JJAP.43.L877
Publication status	Published - 2004 Jul 1

Keywords

Drug delivery
Laser-induced stress wave
Photodynamic therapy
Photofrin II
Photosensitizer
Plasma membrane
Targeting

ASJC Scopus subject areas

Engineering(all)
Physics and Astronomy(all)

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10.1143/JJAP.43.L877

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title = "Enhanced photodynamic effect by the assistance of nanosecond-pulsed-laser- induced stress wave",

abstract = "We demonstrated that phototoxicity was enhanced by applying a single nanosecond-pulsed-laser-induced stress wave (LISW) to cultured cells before photodynamic treatment. Observation with a confocal laser scanning microscope showed that the enhanced phototoxicity is attributable to the larger cellular uptake of a photosensitizer due to the effect of LISW. It was also confirmed that the application of LISW alone did not reduce the cell viability.",

keywords = "Drug delivery, Laser-induced stress wave, Photodynamic therapy, Photofrin II, Photosensitizer, Plasma membrane, Targeting",

author = "Mitsuhiro Terakawa and Shunichi Sato and Satoko Kawauchi and Hiroshi Ashida and Minoru Obara",

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language = "English",

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T1 - Enhanced photodynamic effect by the assistance of nanosecond-pulsed-laser- induced stress wave

AU - Terakawa, Mitsuhiro

AU - Sato, Shunichi

AU - Kawauchi, Satoko

AU - Ashida, Hiroshi

AU - Obara, Minoru

PY - 2004/7/1

Y1 - 2004/7/1

N2 - We demonstrated that phototoxicity was enhanced by applying a single nanosecond-pulsed-laser-induced stress wave (LISW) to cultured cells before photodynamic treatment. Observation with a confocal laser scanning microscope showed that the enhanced phototoxicity is attributable to the larger cellular uptake of a photosensitizer due to the effect of LISW. It was also confirmed that the application of LISW alone did not reduce the cell viability.

AB - We demonstrated that phototoxicity was enhanced by applying a single nanosecond-pulsed-laser-induced stress wave (LISW) to cultured cells before photodynamic treatment. Observation with a confocal laser scanning microscope showed that the enhanced phototoxicity is attributable to the larger cellular uptake of a photosensitizer due to the effect of LISW. It was also confirmed that the application of LISW alone did not reduce the cell viability.

KW - Drug delivery

KW - Laser-induced stress wave

KW - Photodynamic therapy

KW - Photofrin II

KW - Photosensitizer

KW - Plasma membrane

KW - Targeting

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JO - Japanese Journal of Applied Physics, Part 2: Letters

JF - Japanese Journal of Applied Physics, Part 2: Letters

IS - 7 A

ER -

Enhanced photodynamic effect by the assistance of nanosecond-pulsed-laser- induced stress wave

Abstract

Keywords

ASJC Scopus subject areas

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