Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes

Tatsuhiro Masaoka, Hidekazu Suzuki, Hiroshi Hosoda, Takayuki Ota, Yuriko Minegishi, Hiroshi Nagata, Kenji Kangawa, Hiromasa Ishii

Research output: Contribution to journalArticlepeer-review

81 Citations (Scopus)


Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream.

Original languageEnglish
Pages (from-to)64-68
Number of pages5
JournalFEBS Letters
Issue number1-3
Publication statusPublished - 2003 Apr 24
Externally publishedYes


  • Diabetes
  • Ghrelin
  • Growth hormone
  • Preproghrelin
  • Stomach

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


Dive into the research topics of 'Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes'. Together they form a unique fingerprint.

Cite this