Enzyme-mediated optical resolution of 2-methyl-3,4-pentadien-1-ol, a chiral building block possessing terminal allenyl group

Tadayoshi Konegawa; Yoshikazu Ohtsuka; Hajime Ikeda; Takeshi Sugai; Hiromichi Ohta

doi:10.1055/s-1997-1034

Enzyme-mediated optical resolution of 2-methyl-3,4-pentadien-1-ol, a chiral building block possessing terminal allenyl group

Tadayoshi Konegawa, Yoshikazu Ohtsuka, Hajime Ikeda, Takeshi Sugai, Hiromichi Ohta

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Both enantiomers (>95% e.e.) of 2-methyl-3,4-pentadien-1-ol, a chiral building block possessing a terminal allenyl group were prepared via the two-stage enzymatic kinetic resolution, i.e., a sequence of lipase-catalyzed acetylation (Pseudomonas cepacia) and hydrolysis (Candida antarctica).

Original language	English
Pages (from-to)	1297-1299
Number of pages	3
Journal	Synlett
Volume	1997
Issue number	11
DOIs	https://doi.org/10.1055/s-1997-1034
Publication status	Published - 1997

ASJC Scopus subject areas

Organic Chemistry

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10.1055/s-1997-1034

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abstract = "Both enantiomers (>95% e.e.) of 2-methyl-3,4-pentadien-1-ol, a chiral building block possessing a terminal allenyl group were prepared via the two-stage enzymatic kinetic resolution, i.e., a sequence of lipase-catalyzed acetylation (Pseudomonas cepacia) and hydrolysis (Candida antarctica).",

author = "Tadayoshi Konegawa and Yoshikazu Ohtsuka and Hajime Ikeda and Takeshi Sugai and Hiromichi Ohta",

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doi = "10.1055/s-1997-1034",

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T1 - Enzyme-mediated optical resolution of 2-methyl-3,4-pentadien-1-ol, a chiral building block possessing terminal allenyl group

AU - Konegawa, Tadayoshi

AU - Ohtsuka, Yoshikazu

AU - Ikeda, Hajime

AU - Sugai, Takeshi

AU - Ohta, Hiromichi

PY - 1997

Y1 - 1997

N2 - Both enantiomers (>95% e.e.) of 2-methyl-3,4-pentadien-1-ol, a chiral building block possessing a terminal allenyl group were prepared via the two-stage enzymatic kinetic resolution, i.e., a sequence of lipase-catalyzed acetylation (Pseudomonas cepacia) and hydrolysis (Candida antarctica).

AB - Both enantiomers (>95% e.e.) of 2-methyl-3,4-pentadien-1-ol, a chiral building block possessing a terminal allenyl group were prepared via the two-stage enzymatic kinetic resolution, i.e., a sequence of lipase-catalyzed acetylation (Pseudomonas cepacia) and hydrolysis (Candida antarctica).

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JF - Synlett

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ER -

Enzyme-mediated optical resolution of 2-methyl-3,4-pentadien-1-ol, a chiral building block possessing terminal allenyl group

Abstract

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