Eosinophil polyunsaturated fatty acid metabolism and its potential control of inflammation and allergy

Makoto Arita

doi:10.1016/j.alit.2016.05.010

Eosinophil polyunsaturated fatty acid metabolism and its potential control of inflammation and allergy

Makoto Arita

School of Pharmacy

Research output: Contribution to journal › Review article › peer-review

23 Citations (Scopus)

Abstract

Polyunsaturated fatty acids (PUFAs) exhibit a range of biological effects, many of which are mediated through the formation and actions of their bioactive metabolites. It is well appreciated that dietary PUFA balance affects inflammation and/or allergic diseases, and recent advances in liquid chromatography tandem mass spectrometry (LC-MS/MS)-based mediator lipidomics have revealed a potential link between PUFA metabolism and biological phenotypes. This review presents insights into the emerging roles of eosinophil PUFA metabolism in controlling inflammatory responses and its potential involvement in allergy control.

Original language	English
Pages (from-to)	S2-S5
Journal	Allergology International
Volume	65
DOIs	https://doi.org/10.1016/j.alit.2016.05.010
Publication status	Published - 2016 Sept 1

Keywords

Eosinophil
Lipid mediator
Lipidomics
Lipoxygenase
n-3 fatty acid

ASJC Scopus subject areas

Immunology and Allergy

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10.1016/j.alit.2016.05.010

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title = "Eosinophil polyunsaturated fatty acid metabolism and its potential control of inflammation and allergy",

abstract = "Polyunsaturated fatty acids (PUFAs) exhibit a range of biological effects, many of which are mediated through the formation and actions of their bioactive metabolites. It is well appreciated that dietary PUFA balance affects inflammation and/or allergic diseases, and recent advances in liquid chromatography tandem mass spectrometry (LC-MS/MS)-based mediator lipidomics have revealed a potential link between PUFA metabolism and biological phenotypes. This review presents insights into the emerging roles of eosinophil PUFA metabolism in controlling inflammatory responses and its potential involvement in allergy control.",

keywords = "Eosinophil, Lipid mediator, Lipidomics, Lipoxygenase, n-3 fatty acid",

author = "Makoto Arita",

note = "Funding Information: This work was supported in part by funding from the Japan Science and Technology Agency , Precursory Research for Embryonic Science and Technology (PRESTO), a Grant-in-aid for Scientific Research B and Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science, and Technology of Japan , and Science and Technology Research Promotion Program for Agriculture, Forestry, Fisheries and Food industry . Publisher Copyright: {\textcopyright} 2016 Japanese Society of Allergology",

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AU - Arita, Makoto

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PY - 2016/9/1

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N2 - Polyunsaturated fatty acids (PUFAs) exhibit a range of biological effects, many of which are mediated through the formation and actions of their bioactive metabolites. It is well appreciated that dietary PUFA balance affects inflammation and/or allergic diseases, and recent advances in liquid chromatography tandem mass spectrometry (LC-MS/MS)-based mediator lipidomics have revealed a potential link between PUFA metabolism and biological phenotypes. This review presents insights into the emerging roles of eosinophil PUFA metabolism in controlling inflammatory responses and its potential involvement in allergy control.

AB - Polyunsaturated fatty acids (PUFAs) exhibit a range of biological effects, many of which are mediated through the formation and actions of their bioactive metabolites. It is well appreciated that dietary PUFA balance affects inflammation and/or allergic diseases, and recent advances in liquid chromatography tandem mass spectrometry (LC-MS/MS)-based mediator lipidomics have revealed a potential link between PUFA metabolism and biological phenotypes. This review presents insights into the emerging roles of eosinophil PUFA metabolism in controlling inflammatory responses and its potential involvement in allergy control.

KW - Eosinophil

KW - Lipid mediator

KW - Lipidomics

KW - Lipoxygenase

KW - n-3 fatty acid

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DO - 10.1016/j.alit.2016.05.010

M3 - Review article

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SN - 1323-8930

VL - 65

SP - S2-S5

JO - Allergology International

JF - Allergology International

ER -

Eosinophil polyunsaturated fatty acid metabolism and its potential control of inflammation and allergy

Abstract

Keywords

ASJC Scopus subject areas

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