Eph and ephrin interactions in bone

Research output: Chapter in Book/Report/Conference proceedingConference contribution

35 Citations (Scopus)


Bone cells communicate with each other using various cell surface molecules. Membrane-bound ephrin ligands and Eph tyrosine kinase receptors have been characterized in diverse biological processes, including angiogenesis and neuronal development. Several ephrins and Ephs are expressed in osteoclasts and osteoblasts and regulate bone mineral metabolism through bidirectional signaling into not only receptor-expressing cells but also into ligand-expressing cells. We propose that interaction between ephrinB2-expressing osteoclasts and EphB4-expressing osteoblasts facilitates the transition from bone resorption to bone formation during bone remodeling. Other groups have reported the regulation of ephrinB2 by PTH or PTHrP and the possible involvement of EphB4 in osteoarthritis. It is likely that various ephrins and Ephs mediate interaction among bone cells.

Original languageEnglish
Title of host publicationOsteoimmunology
Subtitle of host publicationInteractions of the Immune and Skeletal Systems II
EditorsYongwon Choi
Number of pages9
Publication statusPublished - 2010 Dec 1

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598


  • Bone remodeling
  • Eph
  • Ephrin
  • Osteoclast

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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