Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases

Akiharu Kubo, Keisuke Nagao, Masayuki Amagai

Research output: Contribution to journalReview articlepeer-review

260 Citations (Scopus)


Classic atopic dermatitis is complicated by asthma, allergic rhinitis, and food allergies, cumulatively referred to as atopic diseases. Recent discoveries of mutations in the filaggrin gene as predisposing factors for atopic diseases have refocused investigators' attention on epidermal barrier dysfunction as a causative mechanism. The skin's barrier function has three elements: the stratum corneum (air-liquid barrier), tight junctions (liquid-liquid barrier), and the Langerhans cell network (immunological barrier). Clarification of the molecular events underpinning epidermal barrier function and dysfunction should lead to a better understanding of the pathophysiological mechanisms of atopic diseases.

Original languageEnglish
Pages (from-to)440-447
Number of pages8
JournalJournal of Clinical Investigation
Issue number2
Publication statusPublished - 2012 Feb

ASJC Scopus subject areas

  • Medicine(all)


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