Epigenetic mechanisms in sequential differentiation of neural stem cells

Tsukasa Sanosaka; Masakazu Namihira; Kinichi Nakashima

doi:10.4161/epi.4.2.8233

Epigenetic mechanisms in sequential differentiation of neural stem cells

Tsukasa Sanosaka, Masakazu Namihira, Kinichi Nakashima

Research output: Contribution to journal › Review article › peer-review

30 Citations (Scopus)

Abstract

The major cell types in the central nervous system, neurons and glial cells (astrocytes and oligodendrocytes), are generated from common neural stem cells (NSCs). However, neurogenesis precedes gliogenesis, which normally commences at later stages of fetal brain development. Recent studies have shown that epigenetic gene regulation, in concert with cues from outside the cells, plays important roles in regulating the differentiation potential and fate specification of NSCs. In this review, we discuss emerging molecular explanations for the transitions that occur during the stepwise process of NSC fate specification.

Original language	English
Pages (from-to)	89-92
Number of pages	4
Journal	Epigenetics
Volume	4
Issue number	2
DOIs	https://doi.org/10.4161/epi.4.2.8233
Publication status	Published - 2009 Feb 16
Externally published	Yes

Keywords

DNA methylation
Epigenetics
NFIA
Neural stem cell
Notch

ASJC Scopus subject areas

Molecular Biology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/epi.4.2.8233

Cite this

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title = "Epigenetic mechanisms in sequential differentiation of neural stem cells",

abstract = "The major cell types in the central nervous system, neurons and glial cells (astrocytes and oligodendrocytes), are generated from common neural stem cells (NSCs). However, neurogenesis precedes gliogenesis, which normally commences at later stages of fetal brain development. Recent studies have shown that epigenetic gene regulation, in concert with cues from outside the cells, plays important roles in regulating the differentiation potential and fate specification of NSCs. In this review, we discuss emerging molecular explanations for the transitions that occur during the stepwise process of NSC fate specification.",

keywords = "DNA methylation, Epigenetics, NFIA, Neural stem cell, Notch",

author = "Tsukasa Sanosaka and Masakazu Namihira and Kinichi Nakashima",

note = "Funding Information: We apologize to those colleagues whose work, although relevant to this subject, may not have been included in this review due to space constraints. We thank Dr. Ian Smith for helpful comments and critical reading of the manuscript. This work has been supported by a Grant-in-Aid for Science Research on Priority Areas and by the NAIST Global COE Program (Frontier Biosciences: Strategies for survival and adaptation in a changing global environment), both from the Ministry of Education, Culture, Sports, Science and Technology of Japan.",

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AU - Sanosaka, Tsukasa

AU - Namihira, Masakazu

AU - Nakashima, Kinichi

N1 - Funding Information: We apologize to those colleagues whose work, although relevant to this subject, may not have been included in this review due to space constraints. We thank Dr. Ian Smith for helpful comments and critical reading of the manuscript. This work has been supported by a Grant-in-Aid for Science Research on Priority Areas and by the NAIST Global COE Program (Frontier Biosciences: Strategies for survival and adaptation in a changing global environment), both from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

PY - 2009/2/16

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N2 - The major cell types in the central nervous system, neurons and glial cells (astrocytes and oligodendrocytes), are generated from common neural stem cells (NSCs). However, neurogenesis precedes gliogenesis, which normally commences at later stages of fetal brain development. Recent studies have shown that epigenetic gene regulation, in concert with cues from outside the cells, plays important roles in regulating the differentiation potential and fate specification of NSCs. In this review, we discuss emerging molecular explanations for the transitions that occur during the stepwise process of NSC fate specification.

AB - The major cell types in the central nervous system, neurons and glial cells (astrocytes and oligodendrocytes), are generated from common neural stem cells (NSCs). However, neurogenesis precedes gliogenesis, which normally commences at later stages of fetal brain development. Recent studies have shown that epigenetic gene regulation, in concert with cues from outside the cells, plays important roles in regulating the differentiation potential and fate specification of NSCs. In this review, we discuss emerging molecular explanations for the transitions that occur during the stepwise process of NSC fate specification.

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KW - Epigenetics

KW - NFIA

KW - Neural stem cell

KW - Notch

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Epigenetic mechanisms in sequential differentiation of neural stem cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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