Epigenetic mechanisms in sequential differentiation of neural stem cells

Tsukasa Sanosaka, Masakazu Namihira, Kinichi Nakashima

Research output: Contribution to journalReview articlepeer-review

30 Citations (Scopus)


The major cell types in the central nervous system, neurons and glial cells (astrocytes and oligodendrocytes), are generated from common neural stem cells (NSCs). However, neurogenesis precedes gliogenesis, which normally commences at later stages of fetal brain development. Recent studies have shown that epigenetic gene regulation, in concert with cues from outside the cells, plays important roles in regulating the differentiation potential and fate specification of NSCs. In this review, we discuss emerging molecular explanations for the transitions that occur during the stepwise process of NSC fate specification.

Original languageEnglish
Pages (from-to)89-92
Number of pages4
Issue number2
Publication statusPublished - 2009 Feb 16
Externally publishedYes


  • DNA methylation
  • Epigenetics
  • NFIA
  • Neural stem cell
  • Notch

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research


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