TY - JOUR
T1 - Epstein-Barr Virus-Associated Posttransplant Lymphoproliferative Disorder after a Cord Blood Stem Cell Transplantation Presenting with Pulmonary Nodules
AU - Shimasaki, Noriko
AU - Mori, Tetsuya
AU - Shimada, Hiroyuki
AU - Sugita, Mayumi
AU - Higuchi, Masataka
AU - Mukai, Makio
AU - Morio, Tomohiro
AU - Okamoto, Shinichiro
PY - 2004/2/1
Y1 - 2004/2/1
N2 - Sixteen months after a cord blood stem cell transplantation, a 6-year-old girl was diagnosed with Epstein-Barr virus-associated posttransplant lymphoproliferative disorder (EBV-PTLD). A CT scan revealed nodules in both lungs, but the patient had neither lymphadenopathy nor other lesions. The diagnosis was confirmed by histopathologic evaluation and the increased level of EBV DNA in the peripheral blood. The patient was successfully treated with rituximab, and a complete regression of the tumors was achieved. This case reveals the need to include EBV-PTLD in the differential diagnosis of pulmonary nodules, as well as demonstrating that rituximab may be effective treatment of EBV-PTLD after cord blood stem cell transplantation.
AB - Sixteen months after a cord blood stem cell transplantation, a 6-year-old girl was diagnosed with Epstein-Barr virus-associated posttransplant lymphoproliferative disorder (EBV-PTLD). A CT scan revealed nodules in both lungs, but the patient had neither lymphadenopathy nor other lesions. The diagnosis was confirmed by histopathologic evaluation and the increased level of EBV DNA in the peripheral blood. The patient was successfully treated with rituximab, and a complete regression of the tumors was achieved. This case reveals the need to include EBV-PTLD in the differential diagnosis of pulmonary nodules, as well as demonstrating that rituximab may be effective treatment of EBV-PTLD after cord blood stem cell transplantation.
KW - Chronic graft-versus-host disease
KW - Cord blood stem cell transplantation
KW - Epstein-Barr virus
KW - Lung
KW - Posttransplant lymphoproliferative disorder
KW - Rituximab
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U2 - 10.1097/00043426-200402000-00015
DO - 10.1097/00043426-200402000-00015
M3 - Article
C2 - 14767205
AN - SCOPUS:0442293655
SN - 1077-4114
VL - 26
SP - 124
EP - 127
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
IS - 2
ER -