TY - JOUR
T1 - Establishment of an induced pluripotent stem cell line from a female domestic ferret (Mustela putorius furo) with an X chromosome instability
AU - Yoshimatsu, Sho
AU - Murakami, Rei
AU - Nakajima, Mayutaka
AU - Sato, Tsukika
AU - Kawasaki, Hiroshi
AU - Okano, Hideyuki
N1 - Funding Information:
We especially thank Drs. Hirotaka Watanabe and Takashi Sasaki (Keio University) for supporting this study. We also thank all the laboratory members of H.O. for their encouragement and generous support. Data were obtained in the “Construction of System for Spread of Primate Model Animals” project, performed under the Strategic Research Program for Brain Sciences and Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) of the AMED (Grant ID: JP21dm0207001 to H.O.). This study was also supported by JSPS KAKENHI Grant Number 19J12871 and 20K22660 (to S.Y).
Funding Information:
We especially thank Drs. Hirotaka Watanabe and Takashi Sasaki (Keio University) for supporting this study. We also thank all the laboratory members of H.O. for their encouragement and generous support. Data were obtained in the “Construction of System for Spread of Primate Model Animals” project, performed under the Strategic Research Program for Brain Sciences and Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) of the AMED (Grant ID: JP21dm0207001 to H.O.). This study was also supported by JSPS KAKENHI Grant Number 19J12871 and 20K22660 (to S.Y).
Publisher Copyright:
© 2021 The Author(s)
PY - 2021/5
Y1 - 2021/5
N2 - The domestic ferret (ferret; Mustela putorius furo) is an important animal model for neuroscience and preclinical/veterinary medicine owing to its highly developed cerebral cortex and susceptibility to avian influenza and corona viruses. Nevertheless, there is a lack of in vitro ferret models, since immortal cell lines including induced pluripotent stem cells (iPSCs) of ferrets have been scarce. In this study, we established an iPSC line from ferret skin fibroblasts. The established iPSC line, fiPS-1, showed standard characteristics of pluripotency, but its X chromosome was unstable. Collectively, the present study provides a useful resource for in vitro model using the ferret.
AB - The domestic ferret (ferret; Mustela putorius furo) is an important animal model for neuroscience and preclinical/veterinary medicine owing to its highly developed cerebral cortex and susceptibility to avian influenza and corona viruses. Nevertheless, there is a lack of in vitro ferret models, since immortal cell lines including induced pluripotent stem cells (iPSCs) of ferrets have been scarce. In this study, we established an iPSC line from ferret skin fibroblasts. The established iPSC line, fiPS-1, showed standard characteristics of pluripotency, but its X chromosome was unstable. Collectively, the present study provides a useful resource for in vitro model using the ferret.
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U2 - 10.1016/j.scr.2021.102385
DO - 10.1016/j.scr.2021.102385
M3 - Article
C2 - 34088013
AN - SCOPUS:85105563408
SN - 1873-5061
VL - 53
JO - Stem Cell Research
JF - Stem Cell Research
M1 - 102385
ER -