TY - GEN
T1 - Estimation of protein networks based on least squares method for pseudo-periodic signals
AU - Takahashi, Noriko
AU - Azuma, Takehito
AU - Ito, Mayumi
AU - Adachi, Shuichi
PY - 2011/11/9
Y1 - 2011/11/9
N2 - In this paper, a new approach to estimation problems of protein networks is proposed for systems biology. Generally, it is difficult to estimate complicated networks in molecular biology. In order to estimate complicated networks systematically, it is considered to estimate the networks based on system identification in control engineering. Considering that wave patterns of proteins are pseudo- periodic, the protein networks are estimated by the least- squares estimation method. In this method, the networks can be estimated by using just 1 cycle data of protein concentrations. Moreover, this method is applied to an estimation problem of protein networks for cell cycle in yeast, and 9-dimensional protein networks are actually estimated.
AB - In this paper, a new approach to estimation problems of protein networks is proposed for systems biology. Generally, it is difficult to estimate complicated networks in molecular biology. In order to estimate complicated networks systematically, it is considered to estimate the networks based on system identification in control engineering. Considering that wave patterns of proteins are pseudo- periodic, the protein networks are estimated by the least- squares estimation method. In this method, the networks can be estimated by using just 1 cycle data of protein concentrations. Moreover, this method is applied to an estimation problem of protein networks for cell cycle in yeast, and 9-dimensional protein networks are actually estimated.
KW - Cell cycle
KW - Identification
KW - Least-squares method
KW - Protein networks
KW - Systems biology
UR - http://www.scopus.com/inward/record.url?scp=80455150185&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80455150185&partnerID=8YFLogxK
U2 - 10.2316/P.2011.744-028
DO - 10.2316/P.2011.744-028
M3 - Conference contribution
AN - SCOPUS:80455150185
SN - 9780889868892
T3 - Proceedings of the IASTED International Conference on Intelligent Systems and Control
SP - 48
EP - 54
BT - Proceedings of the 13th IASTED International Conference on Intelligent Systems and Control, ISC 2011
T2 - 13th IASTED International Conference on Intelligent Systems and Control, ISC 2011
Y2 - 11 July 2011 through 13 July 2011
ER -