Ewing sarcoma/primitive neuroectodermal tumor of the kidney treated with chemotherapy including ifosfamide

Hiroki Yoshihara; Takahiro Kamiya; Yosuke Hosoya; Daisuke Hasegawa; Chitose Ogawa; Hiroshi Asanuma; Ryuichi Mizuno; Ryota Hosoya; Atsushi Manabe

doi:10.1111/ped.12963

Ewing sarcoma/primitive neuroectodermal tumor of the kidney treated with chemotherapy including ifosfamide

Hiroki Yoshihara, Takahiro Kamiya, Yosuke Hosoya, Daisuke Hasegawa, Chitose Ogawa, Hiroshi Asanuma, Ryuichi Mizuno, Ryota Hosoya, Atsushi Manabe

Department of Urology

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) of the kidney is extremely rare, and is usually diagnosed after nephrectomy without neoadjuvant chemotherapy. Although ifosfamide and etoposide improve survival to a great extent in ES/PNET, the use of nephrotoxic agent, particularly ifosfamide, is a concern after nephrectomy. We describe the case of a 14-year-old female patient with abdominal mass who was diagnosed with ES/PNET of the right kidney after nephrectomy. Adjuvant chemotherapy including ifosfamide and etoposide were given. The estimated glomerular filtration rate decreased to 75% after the end of therapy. There was no evidence of recurrence 70 months after initial diagnosis.

Original language	English
Pages (from-to)	766-769
Number of pages	4
Journal	Pediatrics International
Volume	58
Issue number	8
DOIs	https://doi.org/10.1111/ped.12963
Publication status	Published - 2016 Aug 1

Keywords

Ewing sarcoma
drug toxicity
ifosfamide
primitive neuroectodermal tumor
renal tumor

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1111/ped.12963

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title = "Ewing sarcoma/primitive neuroectodermal tumor of the kidney treated with chemotherapy including ifosfamide",

abstract = "Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) of the kidney is extremely rare, and is usually diagnosed after nephrectomy without neoadjuvant chemotherapy. Although ifosfamide and etoposide improve survival to a great extent in ES/PNET, the use of nephrotoxic agent, particularly ifosfamide, is a concern after nephrectomy. We describe the case of a 14-year-old female patient with abdominal mass who was diagnosed with ES/PNET of the right kidney after nephrectomy. Adjuvant chemotherapy including ifosfamide and etoposide were given. The estimated glomerular filtration rate decreased to 75% after the end of therapy. There was no evidence of recurrence 70 months after initial diagnosis.",

keywords = "Ewing sarcoma, drug toxicity, ifosfamide, primitive neuroectodermal tumor, renal tumor",

author = "Hiroki Yoshihara and Takahiro Kamiya and Yosuke Hosoya and Daisuke Hasegawa and Chitose Ogawa and Hiroshi Asanuma and Ryuichi Mizuno and Ryota Hosoya and Atsushi Manabe",

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doi = "10.1111/ped.12963",

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T1 - Ewing sarcoma/primitive neuroectodermal tumor of the kidney treated with chemotherapy including ifosfamide

AU - Yoshihara, Hiroki

AU - Kamiya, Takahiro

AU - Hosoya, Yosuke

AU - Hasegawa, Daisuke

AU - Ogawa, Chitose

AU - Asanuma, Hiroshi

AU - Mizuno, Ryuichi

AU - Hosoya, Ryota

AU - Manabe, Atsushi

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) of the kidney is extremely rare, and is usually diagnosed after nephrectomy without neoadjuvant chemotherapy. Although ifosfamide and etoposide improve survival to a great extent in ES/PNET, the use of nephrotoxic agent, particularly ifosfamide, is a concern after nephrectomy. We describe the case of a 14-year-old female patient with abdominal mass who was diagnosed with ES/PNET of the right kidney after nephrectomy. Adjuvant chemotherapy including ifosfamide and etoposide were given. The estimated glomerular filtration rate decreased to 75% after the end of therapy. There was no evidence of recurrence 70 months after initial diagnosis.

AB - Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) of the kidney is extremely rare, and is usually diagnosed after nephrectomy without neoadjuvant chemotherapy. Although ifosfamide and etoposide improve survival to a great extent in ES/PNET, the use of nephrotoxic agent, particularly ifosfamide, is a concern after nephrectomy. We describe the case of a 14-year-old female patient with abdominal mass who was diagnosed with ES/PNET of the right kidney after nephrectomy. Adjuvant chemotherapy including ifosfamide and etoposide were given. The estimated glomerular filtration rate decreased to 75% after the end of therapy. There was no evidence of recurrence 70 months after initial diagnosis.

KW - Ewing sarcoma

KW - drug toxicity

KW - ifosfamide

KW - primitive neuroectodermal tumor

KW - renal tumor

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Ewing sarcoma/primitive neuroectodermal tumor of the kidney treated with chemotherapy including ifosfamide

Abstract

Keywords

ASJC Scopus subject areas

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