Execution mechanisms of programmed cell death by caspase (ICE/CED-3) family proteases

Masayuki Miura, Shin Hisahara, Takashi Araki, Hideyuki Okano

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Molecular genetic study of Caenorhabditis elegans revealed the cell death-executing gene ced-3. Structural and functional similarities between CED-3 and mammalian ICE family (caspase) gene products provide the evidence that mammalian caspases are common mediators in executing programmed cell death. These findings suggest that the execution mechanisms of cell death by caspase family protease may be evolutionarily conserved from worms to mammals. This report summarizes the unique properties of caspases in apoptosis.

Original languageEnglish
Pages (from-to)66-70
Number of pages5
JournalHeart and vessels
Issue numberSUPPL. 12
Publication statusPublished - 1997 Dec 1
Externally publishedYes


  • Apoptosis
  • CED-3
  • Caspase
  • ICE
  • Programmed cell death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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