Abstract
Proto-oncogene c-mos, the cellular homologue of the transforming gene of Molony murine sarcoma virus, has been characterized by the lack of expression in a variety of differentiated tissues, possibly because of the existence of an inhibitory upstream sequence. We detected mos-related transcripts in undifferentiated embryonal carcinoma cells of pluripotential cell line 311. The sizes of three major transcripts detected were estimated to be 1.8, 4.6 and 6.1-kilobases(kb) by northern analysis. Furthermore, these transcriptions were suppressed when the cell differentiation was induced by retinoic acid. Taken together, the results suggest that mos product plays a role in early stages of development.
| Original language | English |
|---|---|
| Pages (from-to) | 477-484 |
| Number of pages | 8 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 140 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1986 Oct 30 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology
Fingerprint
Dive into the research topics of 'Expression of c-mos proto-oncogene in undifferentiated teratocarcinoma cells'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS