Expression of histamine H4 receptor in human synovial cells and dermal tissues

Yoshiko Matsuda, Katsunori Yamaura, Masahiko Suzuki, Takao Namiki, Koichi Ueno

Research output: Chapter in Book/Report/Conference proceedingChapter


The last of the four histamine receptors, H4 receptor (H4R), was identified in the year 2000. Since that time, H4R has been implicated in cellular mechanisms related to immune systems, inflammatory processes, and allergic reactions. We reported the expression of H4R in rheumatoid arthritis (RA) synovial cell cultures and human dermal tissues. In the synovial cell cultures, two specific types of cell populations, fibroblast-like and macrophage-like cells, both showed expression of H4R. We also demonstrated H4R expression in human dermal fibroblast and epidermal tissue. When investigating the effect of histamine H4R antagonists on pruritus using a mouse model, JNJ7777120, a H4R antagonist, was found to significantly reduce histamine- and substance P-induced scratching. These results suggest that H4R may be useful for treatment rheumatoid arthritis or pruritus.

Original languageEnglish
Title of host publicationBiomedical Aspects of Histamine
Subtitle of host publicationCurrent Perspectives
PublisherSpringer Netherlands
Number of pages9
ISBN (Print)9789048193486
Publication statusPublished - 2011
Externally publishedYes


  • H4R-antagonists
  • Histamine H4 receptors
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • General Engineering


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