Expression of interstitial collagenase (matrix metalloproteinase-1) in gastric cancers

Yoshihiko Sakurai, Yoshihide Otani, Kaori Kameyama, Yasuhiro Hosoda, Isao Okazaki, Tetsuro Kubota, Koichiro Kumai, Masaki Kitajima

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25 Citations (Scopus)


The expression of matrix metalloproteinase-1 (MMP-1) gene and the presence of MMP-1 protein in gastric cancer were examined by in situ hybridization and immunohistochemistry. Expression of the interstitial collagenase (MMP-1) gene was detected within the stroma of the neoplastic glands, and infiltration of eosinophils was observed to be associated with regions of MMP-1 gene expression. The degree of eosinophilic infiltration correlated with the level of MMP-1 mRNA expression. Immunostaining showed localization of MMP-1 protein in the stromal cells, and additionally in the neoplastic glands. These findings indicate that the stromal cells may play an important role in the expression of MMP-1, and suggest a pathophysiological role for MMP-1 in the invasion and metastasis of gastric cancer.

Original languageEnglish
Pages (from-to)401-406
Number of pages6
JournalJapanese Journal of Cancer Research
Issue number4
Publication statusPublished - 1997


  • Collagenase
  • Eosinophil
  • Gastric cancer
  • Matrix metalloproteinase-1
  • Stromal cell

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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