Expression of MMP-1 in the capsule of thyroid cancer - Relationship with invasiveness

K. Kameyama

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


To investigate the invasive activity of thyroid cancer, an in situ hybridization study was carried out in 19 thyroid tumors, including nine papillary carcinomas, five follicular carcinomas and five follicular adenomas, by using a 35S-labeled MMP-1 (matrix metalloproteinase-1) cDNA probe. The MMP-1 gene was expressed not in the cancer cells but in the fibrous capsules of papillary carcinoma. Thyroid cancer is generally circumscribed by a fibrous capsule. We found that types I and III collagen constitute the fibrous capsule, and that the MMP-1 gene was expressed in the outer border of these sites. These findings suggest that MMP-1 plays an important role in the invasion of thyroid cancer.

Original languageEnglish
Pages (from-to)20-26
Number of pages7
JournalPathology Research and Practice
Issue number1
Publication statusPublished - 1996 Jan


  • Collagenase
  • In situ hybridization
  • Invasion
  • Matrix metalloproteinase
  • Thyroid cancer

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology


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