Expression of N-cadherin and α-catenin in astrocytomas and glioblastomas

N. Shinoura, N. E. Paradies, R. E. Warnick, H. Chen, J. J. Larson, J. J. Tew, M. Simon, R. A. Lynch, Y. Kanai, S. Hirohashi, J. J. Hemperly, A. G. Menoni, R. Brackenbury

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)


We examined levels of mRNA and protein for N-cadherin, the predominant cadherin in neural tissues, and mRNA levels for the cadherin-associated protein, alpha-catenin, in a series of gliomas and in glioblastoma cell lines. mRNA levels for N-cadherin and alpha-catenin were significantly higher in glioblastomas than in low-grade astrocytomas or normal brain, while the levels of intact N-cadherin protein were similar in glioblastomas, low-grade astrocytomas and brain. In addition, there was no consistent relationship between invasiveness and expression of N-cadherin and alpha-catenin in highly invasive vs minimally invasive tumours within the same histopathological grade. To assess further the relationship between cadherin expression and neural tumour invasion, we measured N-cadherin expression, calcium-dependent cell adhesion and motility of several glioblastoma cell lines. While all N-cadherin-expressing lines were adhesive, no correlation was seen between the level of N-cadherin expression and cell motility. Together, these findings imply that, in contrast to the role played by E-cadherin in carcinomas, N-cadherin does not restrict the invasion of glioblastomas.

Original languageEnglish
Pages (from-to)627-633
Number of pages7
JournalBritish Journal of Cancer
Issue number3
Publication statusPublished - 1995 Sept
Externally publishedYes


  • Brain tumours
  • Cell adhesion
  • Cell motility
  • Invasion

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Expression of N-cadherin and α-catenin in astrocytomas and glioblastomas'. Together they form a unique fingerprint.

Cite this