TY - JOUR
T1 - Expression of squamous cell carcinoma markers and adenocarcinoma markers in primary pulmonary neuroendocrine carcinomas
AU - Masai, Kyohei
AU - Tsuta, Koji
AU - Kawago, Mitsumasa
AU - Tatsumori, Takahiro
AU - Kinno, Tomoaki
AU - Taniyama, Tomoko
AU - Yoshida, Akihiko
AU - Asamura, Hisao
AU - Tsuda, Hitoshi
PY - 2013/7
Y1 - 2013/7
N2 - Recent clinical trials have revealed that accurate histologic typing of non-small cell lung cancer is essential. Until now, squamous cell carcinoma (SQC) and adenocarcinoma (ADC) markers have not been thoroughly analyzed for pulmonary neuroendocrine carcinomas (NECs). We analyzed the expression of 8 markers [p63, cytokeratin (CK) 5/6, SOX2, CK7, desmocollin 3, thyroid transcription factor-1 (8G7G3/1 and SPT24), and napsin A] in 224 NECs. SOX2 (76.2%) had the greatest expression for NECs. CK5/6 (1.4%), desmocollin 3 (0.5%), and napsin A (0%) were expressed less or not at all in NECs. Although our investigated markers have been reported useful for differentiating between SQC and ADC, some of them were also present in a portion of pulmonary NECs. In our study, CK5/6 and desmocollin 3 were highly specific markers for SQC, and napsin A was highly specific for ADC. These markers are recommended for diagnosis of poorly differentiated non-small cell lung cancer.
AB - Recent clinical trials have revealed that accurate histologic typing of non-small cell lung cancer is essential. Until now, squamous cell carcinoma (SQC) and adenocarcinoma (ADC) markers have not been thoroughly analyzed for pulmonary neuroendocrine carcinomas (NECs). We analyzed the expression of 8 markers [p63, cytokeratin (CK) 5/6, SOX2, CK7, desmocollin 3, thyroid transcription factor-1 (8G7G3/1 and SPT24), and napsin A] in 224 NECs. SOX2 (76.2%) had the greatest expression for NECs. CK5/6 (1.4%), desmocollin 3 (0.5%), and napsin A (0%) were expressed less or not at all in NECs. Although our investigated markers have been reported useful for differentiating between SQC and ADC, some of them were also present in a portion of pulmonary NECs. In our study, CK5/6 and desmocollin 3 were highly specific markers for SQC, and napsin A was highly specific for ADC. These markers are recommended for diagnosis of poorly differentiated non-small cell lung cancer.
KW - immunohistochemical marker
KW - lung
KW - neuroendocrine tumor
UR - http://www.scopus.com/inward/record.url?scp=84880922756&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880922756&partnerID=8YFLogxK
U2 - 10.1097/PAI.0b013e31826fd4f3
DO - 10.1097/PAI.0b013e31826fd4f3
M3 - Article
C2 - 23060301
AN - SCOPUS:84880922756
SN - 1541-2016
VL - 21
SP - 292
EP - 297
JO - Applied Immunohistochemistry and Molecular Morphology
JF - Applied Immunohistochemistry and Molecular Morphology
IS - 4
ER -
