Extended-nano scale fluidics and applications to bioanalysis

Hisashi Shimizu, Kazuma Mawatari, Yutaka Kazoe, Yuriy Pihosh, Takehiko Kitamori

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)


Extended-nano space, which is in 10-1000 nm scale, is a transitional region from single molecules to continuous fluid. Even though many specific effects are expected, device engineering of extended-nano space has not been developed so far due to the lack of basic technologies for fluidic engineering. Previously, our group established a strategy of device integration for microchemical systems called continuous flow chemical processing and applied the strategy to various analytical systems. In addition, we have succeeded in developments of basic technologies including fabrication, fluidic control and detection for extended-nano space to find very unique effects such as higher viscosity, lower dielectric constant and higher proton mobility. In this chapter, the uniqueness, device engineering of extended-nano space and its application to bioanalytical devices are introduced. Especially, we focus on an ultimate chromatography using extended-nano space and its innovative performances to break the limits of conventional technologies.

Original languageEnglish
Title of host publicationIntelligent Nanosystems for Energy, Information and Biological Technologies
PublisherSpringer Japan
Number of pages20
ISBN (Electronic)9784431564294
ISBN (Print)9784431564270
Publication statusPublished - 2016 Jan 1
Externally publishedYes


  • Chromatography
  • Fuel cell
  • Immunoassay
  • Microfluidics
  • Nanofluidics
  • Photothermal spectroscopy

ASJC Scopus subject areas

  • Engineering(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Neuroscience(all)


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