Extracellular vesicle-associated MMPs: A modulator of the tissue microenvironment

Masayuki Shimoda

Research output: Chapter in Book/Report/Conference proceedingChapter

34 Citations (Scopus)


Extracellular vesicles (EVs) are small particles that mediate intercellular communications in local and distant microenvironments. Due to their ability to carry bioactive materials such as proteins, nucleic acids, and lipids, and to transfer their cargo into target cells, EVs are thought to be crucial mediators under pathological and physiological conditions. Recent investigations of their protein profiles have revealed the presence of metalloproteinases such as matrix metalloproteinases (MMPs) in EVs from various cell types and body fluids. Although information regarding the biological and clinical significance of MMPs in EVs is still limited, EV-associated MMPs can alter EV cargo by ectodomain shedding, exerting proteolytic activity following uptake by target cells, or directly contributing to degradation of extracellular matrix proteins surrounding cells. This review focuses on recent findings regarding EV-associated MMPs, and we further discuss their potential involvement in human diseases.

Original languageEnglish
Title of host publicationAdvances in Clinical Chemistry
EditorsGregory S. Makowski
PublisherAcademic Press Inc.
Number of pages32
ISBN (Print)9780128171431
Publication statusPublished - 2019

Publication series

NameAdvances in Clinical Chemistry
ISSN (Print)0065-2423
ISSN (Electronic)2162-9471


  • A disintegrin and metalloproteinase (ADAM)
  • Exosome
  • Extracellular matrix (ECM)
  • Extracellular vesicle (EV)
  • Matrix metalloproteinase (MMP)

ASJC Scopus subject areas

  • General Chemistry
  • Clinical Biochemistry


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