Fabrication of bone like composites material and evaluation of its ossiferous ability

Noriyuki Hisamori, Megumi Kimura, Hikaru Morisue, Morio Matsumoto, Yoshiaki Toyama

Research output: Contribution to journalArticlepeer-review


Many kinds of materials are currently used as artificial bone substitutes. Hydroxyapatite (HA), the same as the main inorganic component of bone, is one of commonly used bio-ceramics and has excellent bioactivity and biocompatibility with hard tissues. However, it has problems as the bone filler or bone tissue-engineering scaffold due to low fracture toughness and low degradation rate. Recently, biodegradable materials for bone tissue have been developed to respond the requirement. Collagen, the same as the main organic component of bone, is biocompatible, biodegradable and promotes cell adhesion. A composites associated with HA is expected to have early osteoconduction and bone replacement ability. The present study was to fabricate bone-like composites consist of HA and collagen. Besides the ossiferous ability of the material in vivo is evaluated by using rabbits. Bone-like composites were successfully fabricated in this study, associating the collagen with HA. And the composites presented good osteoconductive and bone replacement potential.

Original languageEnglish
Pages (from-to)3567-3572
Number of pages6
JournalInternational Journal of Modern Physics B
Issue number25-27
Publication statusPublished - 2006 Oct 30


  • Apatite
  • Bone-like composites
  • Collagen
  • Microstructure
  • Ossiferous ability

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Condensed Matter Physics


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