Factors associated with outcome of egg allergy 1 year after oral food challenge: A good baseline quality of life may be beneficial

Kana Hamada, Mizuho Nagao, Ryo Imakiire, Kanae Furuya, Yumi Mizuno, Yasunori Sato, Mayumi Matsunaga, Shingo Yamada, Kazutaka Nogami, Miyuki Hoshi, Taiga Kobori, Keigo Kainuma, Kazumoto Iijima, Takao Fujisawa

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Background: Safely liberalizing the diet to include an allergenic food may accelerate resolution of food allergy. The outcome of liberalization, however, varies among patients. Methods: We conducted a prospective observational study to identify factors associated with outcome for egg allergy 1 year after oral food challenge (OFC). We enrolled children <72 months old who had egg allergy and underwent OFC for determination of the safe intake quantity of egg allergen. Each child's baseline clinical background was recorded. Caregivers used the Food Allergy Quality of Life Questionnaire-Parent Form (FAQLQ-PF) to assess their children's QoL. Dietary advice based on the OFC result was provided to support safe egg consumption. At 1 year after OFC, the quantity of egg each child safely consumed in daily life was surveyed. We classified the outcome as Successful (Group S) if the quantity increased during the 1 year, or as Unsuccessful (Group U) if it did not. Factors associated with the outcome were investigated by multivariate logistic regression analysis. Results: A total of 93 children were enrolled, and after 1 year, 57 finished in Group S and 36 in Group U. The mean FAQLQ-PF score at baseline was significantly lower (ie, a better QoL) in Group S than in Group U. Multivariate logistic regression analysis identified a good QoL and absence of comorbid asthma or atopic dermatitis as factors predicting a favorable outcome. Conclusion: QoL may affect food allergy outcome. Intervention focusing on the QoL may promote outgrowing of food allergies.

Original languageEnglish
Pages (from-to)1490-1496
Number of pages7
JournalPediatric Allergy and Immunology
Issue number7
Publication statusPublished - 2021 Oct


  • egg hypersensitivity
  • food hypersensitivity
  • quality of life

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'Factors associated with outcome of egg allergy 1 year after oral food challenge: A good baseline quality of life may be beneficial'. Together they form a unique fingerprint.

Cite this