Factors predicting major complications, mortality, and recovery in percutaneous endoscopic gastrostomy

Kenji J.L. Limpias Kamiya, Naoki Hosoe, Kaoru Takabayashi, Yukie Hayashi, Seiichiro Fukuhara, Makoto Mutaguchi, Rieko Nakamura, Hirofumi Kawakubo, Yuko Kitagawa, Haruhiko Ogata, Takanori Kanai

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Background and Aim: Percutaneous endoscopic gastrostomy (PEG) has been used in patients with dysphagia and inadequate food intake via an oral route. Despite being a procedure with a high success rate, complications and death have been reported. The aim was to identify the factors related to major complications and mortality, as well as PEG removal prognostic factors due to improvement of their general condition. Methods: Patient characteristics, comorbidities, laboratory data, concomitant medication, sedation, and indication for PEG placement were collected. Major complications, mortality, and PEG removal factors were assessed. Results: A total of 388 patients were enrolled. There were 15 (3.9%) cases of major complications, with major bleeding being the most frequent in 6 (1.5%) patients. Corticosteroids were the independent variable associated with major complications (odds ratio [OR] 5.85; 95% confidence interval [CI] 1.71–20; P = <0.01). Advanced cancer (hazard ratio [HR] 0.5; 95% CI 0.3–1; P = 0.05), albumin (HR 0.6; 95% CI 0.4–0.9; P = <0.01), and C-reactive protein (CRP) (HR 1.1; CI 1–1.2; P = 0.01) were considered risk factors for mortality. Previous pneumonia (HR 0.4; CI 0.2–0.9; P = 0.02) was a factor for permanent use of a PEG; however, oncological indication (HR 8.2; CI 3.2–21; P = <0.01) was factors for PEG withdrawal. Conclusions: Chronic corticosteroid users potentially present with major complications. Low albumin levels and elevated CRP were associated with death. Previous aspiration pneumonia was a factor associated with permanent use of PEG; however, patients with oncological indication were the most benefited.

Original languageEnglish
Pages (from-to)590-598
Number of pages9
JournalJGH Open
Issue number5
Publication statusPublished - 2021 May


  • corticosteroids
  • major complications
  • oncological indication
  • percutaneous endoscopic gastrostomy

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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