Fatal GVHD demonstrating an involvement of respiratory muscle following donor leukocyte transfusion (DLT)

Y. Oshima; S. Takahashi; H. Nagayama; K. Nishiwaki; Y. Kobayashi; A. Tojo; S. I. Okamoto; K. Tani; K. Ozawa; T. Wakabayashi; N. Sato; S. Kobayashi; K. Nakamura; Y. Ohya; N. Nukina; I. Kanazawa; S. Asano

doi:10.1038/sj.bmt.1700731

Fatal GVHD demonstrating an involvement of respiratory muscle following donor leukocyte transfusion (DLT)

Y. Oshima, S. Takahashi, H. Nagayama, K. Nishiwaki, Y. Kobayashi, A. Tojo, S. I. Okamoto, K. Tani, K. Ozawa, T. Wakabayashi, N. Sato, S. Kobayashi, K. Nakamura, Y. Ohya, N. Nukina, I. Kanazawa, S. Asano

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

A 41-year-old female patient with AML, who relapsed after an allogeneic BMT from her HLA-identical sister, was treated by a donor leukocyte transfusion (DLT). Thereafter, bone marrow aplasia accompanied by the disappearance of leukemic blasts following the GVHD was observed. The patient died of chronic GVHD with respiratory muscle involvement 19 months after the DLT. Although the DLT was considered helpful in suppressing the proliferation of the leukemic cells, it might also have caused the severe GVHD observed in this case. Efforts to separate the lymphocyte clones responsible for GVL from those for the GVHD thus appear to be necessary for the further development of the therapeutic approach, so-called DLT.

Original language	English
Pages (from-to)	737-740
Number of pages	4
Journal	Bone Marrow Transplantation
Volume	19
Issue number	7
DOIs	https://doi.org/10.1038/sj.bmt.1700731
Publication status	Published - 1997 Apr 1
Externally published	Yes

Keywords

BMT
Donor leukocyte transfusion
GVHD
Myositis
Respiratory failure

ASJC Scopus subject areas

Hematology
Transplantation

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10.1038/sj.bmt.1700731

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Oshima, Y., Takahashi, S., Nagayama, H., Nishiwaki, K., Kobayashi, Y., Tojo, A., Okamoto, S. I., Tani, K., Ozawa, K., Wakabayashi, T., Sato, N., Kobayashi, S., Nakamura, K., Ohya, Y., Nukina, N., Kanazawa, I., & Asano, S. (1997). Fatal GVHD demonstrating an involvement of respiratory muscle following donor leukocyte transfusion (DLT). Bone Marrow Transplantation, 19(7), 737-740. https://doi.org/10.1038/sj.bmt.1700731

Oshima, Y, Takahashi, S, Nagayama, H, Nishiwaki, K, Kobayashi, Y, Tojo, A, Okamoto, SI, Tani, K, Ozawa, K, Wakabayashi, T, Sato, N, Kobayashi, S, Nakamura, K, Ohya, Y, Nukina, N, Kanazawa, I & Asano, S 1997, 'Fatal GVHD demonstrating an involvement of respiratory muscle following donor leukocyte transfusion (DLT)', Bone Marrow Transplantation, vol. 19, no. 7, pp. 737-740. https://doi.org/10.1038/sj.bmt.1700731

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abstract = "A 41-year-old female patient with AML, who relapsed after an allogeneic BMT from her HLA-identical sister, was treated by a donor leukocyte transfusion (DLT). Thereafter, bone marrow aplasia accompanied by the disappearance of leukemic blasts following the GVHD was observed. The patient died of chronic GVHD with respiratory muscle involvement 19 months after the DLT. Although the DLT was considered helpful in suppressing the proliferation of the leukemic cells, it might also have caused the severe GVHD observed in this case. Efforts to separate the lymphocyte clones responsible for GVL from those for the GVHD thus appear to be necessary for the further development of the therapeutic approach, so-called DLT.",

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AU - Kobayashi, Y.

AU - Tojo, A.

AU - Okamoto, S. I.

AU - Tani, K.

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AU - Sato, N.

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AU - Nakamura, K.

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AB - A 41-year-old female patient with AML, who relapsed after an allogeneic BMT from her HLA-identical sister, was treated by a donor leukocyte transfusion (DLT). Thereafter, bone marrow aplasia accompanied by the disappearance of leukemic blasts following the GVHD was observed. The patient died of chronic GVHD with respiratory muscle involvement 19 months after the DLT. Although the DLT was considered helpful in suppressing the proliferation of the leukemic cells, it might also have caused the severe GVHD observed in this case. Efforts to separate the lymphocyte clones responsible for GVL from those for the GVHD thus appear to be necessary for the further development of the therapeutic approach, so-called DLT.

KW - BMT

KW - Donor leukocyte transfusion

KW - GVHD

KW - Myositis

KW - Respiratory failure

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Fatal GVHD demonstrating an involvement of respiratory muscle following donor leukocyte transfusion (DLT)

Abstract

Keywords

ASJC Scopus subject areas

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