@article{7f019d75c66042f6b45316fc9ee13113,
title = "Fatty Acid Synthesis Is Indispensable for Survival of Human Pluripotent Stem Cells",
abstract = "Biological",
keywords = "Biological Sciences, Cell Biology, Metabolic Flux Analysis, Metabolomics, Proteomics, Stem Cells Research",
author = "Sho Tanosaki and Shugo Tohyama and Jun Fujita and Shota Someya and Takako Hishiki and Tomomi Matsuura and Hiroki Nakanishi and Takayo Ohto-Nakanishi and Tomohiko Akiyama and Yuika Morita and Yoshikazu Kishino and Marina Okada and Hidenori Tani and Yusuke Soma and Kazuaki Nakajima and Hideaki Kanazawa and Masahiro Sugimoto and Minoru Ko and Makoto Suematsu and Keiichi Fukuda",
note = "Funding Information: The authors thank the Center for iPSC Research and Application, and Kyoto University, for providing hiPSC lines (253G4, 201B7, and FfI14). The authors thank Hideo Shindou and Takao Shimizu for their assistance in liposome preparation. The present work was mainly supported by Projects for Technological Development, Research Center Network for Realization of Regenerative Medicine by Japan, the Japan Agency for Medical Research and Development (AMED) grant 19bm0404023h0002 to S.T., and partly supported by the Highway Program for Realization of Regenerative Medicine from AMED grant 19bk0104062h0003 to K.F. and JSPS KAKENHI grant 17H05067 to S.T. Infrastructure of metabolomics based on CE-MS was supported by Japan Science and Technology ERATO Suematsu Gas Biology (M.S. was the lead from 2010 to 2015). Funding Information: The authors thank the Center for iPSC Research and Application, and Kyoto University, for providing hiPSC lines (253G4, 201B7, and FfI14). The authors thank Hideo Shindou and Takao Shimizu for their assistance in liposome preparation. The present work was mainly supported by Projects for Technological Development, Research Center Network for Realization of Regenerative Medicine by Japan, the Japan Agency for Medical Research and Development (AMED) grant 19bm0404023h0002 to S.T. and partly supported by the Highway Program for Realization of Regenerative Medicine from AMED grant 19bk0104062h0003 to K.F. and JSPS KAKENHI grant 17H05067 to S.T. Infrastructure of metabolomics based on CE-MS was supported by Japan Science and Technology ERATO Suematsu Gas Biology (M.S. was the lead from 2010 to 2015). S. Tohyama conceptualized and designed the study; S. Tanosaki performed and analyzed most experiments; S.S. H.N. T.O.-N. T.H. T.A. K.N. Y.K. M.O. Y.M. H.T. Y.S. and H.K. contributed to specific experiments; S. Tanosaki and S. Tohyama wrote the original draft; S. Tohyama, J.F. and K.F. wrote, reviewed, and edited the manuscript; S. Tohyama, J.F. and K.F. acquired funding; S. Tohyama, J.F. M.S.H.K. M.S. and K.F. supervised the study. S. Tanosaki, S. Tohyama, J.F. and K.F. have a patent pending related to this work. K.F. is a co-founder and CEO of Heartseed, Inc. S. Tohyama is an advisor of Heartseed, Inc. S. Tohyama, J.F. H.K. and K.F. own equity in Heartseed, Inc. The remaining authors have no conflicts of interest to disclose. Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = sep,
day = "25",
doi = "10.1016/j.isci.2020.101535",
language = "English",
volume = "23",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "9",
}