Fecal microbiota transplantation for recurrent Clostridium difficile infection in a patient with ulcerative colitis

Kosaku Nanki; Shinta Mizuno; Katsuyoshi Matsuoka; Keiko Ono; Shinya Sugimoto; Hiroki Kiyohara; Mari Arai; Moeko Nakashima; Kozue Takeshita; Keiichiro Saigusa; Mitsutoshi Senoh; Tadashi Fukuda; Makoto Naganuma; Haru Kato; Wataru Suda; Masahira Hattori; Takanori Kanai

doi:10.5217/ir.2018.16.1.142

Fecal microbiota transplantation for recurrent Clostridium difficile infection in a patient with ulcerative colitis

Kosaku Nanki, Shinta Mizuno, Katsuyoshi Matsuoka, Keiko Ono, Shinya Sugimoto, Hiroki Kiyohara, Mari Arai, Moeko Nakashima, Kozue Takeshita, Keiichiro Saigusa, Mitsutoshi Senoh, Tadashi Fukuda, Makoto Naganuma, Haru Kato, Wataru Suda, Masahira Hattori, Takanori Kanai

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Fecal microbiota transplantation (FMT) has been reported as a safe and effective therapy in patients with refractory and recurrent Clostridium difficile infection (CDI). FMT has also been reported as a promising therapy in patients with ulcerative colitis (UC). Both, CDI and UC, are believed to be caused by dysbiosis, such as altered compositions or decreased diversity of the intestinal microbiota. This report describes a patient with UC in remission with a second recurrent episode of CDI, who was treated with FMT. A single FMT performed via colonoscopy completely resolved the patient's diarrhea and eradicated C. difficile bacteriologically without any severe complications. Molecular biological analysis of the patient's fecal microbiota showed that FMT could dramatically change the altered composition of intestinal microbiota and restore its diversity. Despite the restoration of the intestinal microbiota, FMT could not prevent a relapse of UC in this patient. However, it improved the intestinal symptoms of CDI and could prevent further recurrences of CDI.

Original language	English
Pages (from-to)	142-146
Number of pages	5
Journal	Intestinal Research
Volume	16
Issue number	1
DOIs	https://doi.org/10.5217/ir.2018.16.1.142
Publication status	Published - 2018

Keywords

Clostridium difficile
Colitis
Fecal microbiota transplantation
Ulcerative

ASJC Scopus subject areas

Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5217/ir.2018.16.1.142

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Nanki, K., Mizuno, S., Matsuoka, K., Ono, K., Sugimoto, S., Kiyohara, H., Arai, M., Nakashima, M., Takeshita, K., Saigusa, K., Senoh, M., Fukuda, T., Naganuma, M., Kato, H., Suda, W., Hattori, M., & Kanai, T. (2018). Fecal microbiota transplantation for recurrent Clostridium difficile infection in a patient with ulcerative colitis. Intestinal Research, 16(1), 142-146. https://doi.org/10.5217/ir.2018.16.1.142

Nanki, K, Mizuno, S, Matsuoka, K, Ono, K , Sugimoto, S , Kiyohara, H, Arai, M, Nakashima, M, Takeshita, K, Saigusa, K, Senoh, M, Fukuda, T, Naganuma, M, Kato, H, Suda, W, Hattori, M & Kanai, T 2018, 'Fecal microbiota transplantation for recurrent Clostridium difficile infection in a patient with ulcerative colitis', Intestinal Research, vol. 16, no. 1, pp. 142-146. https://doi.org/10.5217/ir.2018.16.1.142

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abstract = "Fecal microbiota transplantation (FMT) has been reported as a safe and effective therapy in patients with refractory and recurrent Clostridium difficile infection (CDI). FMT has also been reported as a promising therapy in patients with ulcerative colitis (UC). Both, CDI and UC, are believed to be caused by dysbiosis, such as altered compositions or decreased diversity of the intestinal microbiota. This report describes a patient with UC in remission with a second recurrent episode of CDI, who was treated with FMT. A single FMT performed via colonoscopy completely resolved the patient's diarrhea and eradicated C. difficile bacteriologically without any severe complications. Molecular biological analysis of the patient's fecal microbiota showed that FMT could dramatically change the altered composition of intestinal microbiota and restore its diversity. Despite the restoration of the intestinal microbiota, FMT could not prevent a relapse of UC in this patient. However, it improved the intestinal symptoms of CDI and could prevent further recurrences of CDI.",

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author = "Kosaku Nanki and Shinta Mizuno and Katsuyoshi Matsuoka and Keiko Ono and Shinya Sugimoto and Hiroki Kiyohara and Mari Arai and Moeko Nakashima and Kozue Takeshita and Keiichiro Saigusa and Mitsutoshi Senoh and Tadashi Fukuda and Makoto Naganuma and Haru Kato and Wataru Suda and Masahira Hattori and Takanori Kanai",

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AU - Nanki, Kosaku

AU - Mizuno, Shinta

AU - Matsuoka, Katsuyoshi

AU - Ono, Keiko

AU - Sugimoto, Shinya

AU - Kiyohara, Hiroki

AU - Arai, Mari

AU - Nakashima, Moeko

AU - Takeshita, Kozue

AU - Saigusa, Keiichiro

AU - Senoh, Mitsutoshi

AU - Fukuda, Tadashi

AU - Naganuma, Makoto

AU - Kato, Haru

AU - Suda, Wataru

AU - Hattori, Masahira

AU - Kanai, Takanori

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PY - 2018

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N2 - Fecal microbiota transplantation (FMT) has been reported as a safe and effective therapy in patients with refractory and recurrent Clostridium difficile infection (CDI). FMT has also been reported as a promising therapy in patients with ulcerative colitis (UC). Both, CDI and UC, are believed to be caused by dysbiosis, such as altered compositions or decreased diversity of the intestinal microbiota. This report describes a patient with UC in remission with a second recurrent episode of CDI, who was treated with FMT. A single FMT performed via colonoscopy completely resolved the patient's diarrhea and eradicated C. difficile bacteriologically without any severe complications. Molecular biological analysis of the patient's fecal microbiota showed that FMT could dramatically change the altered composition of intestinal microbiota and restore its diversity. Despite the restoration of the intestinal microbiota, FMT could not prevent a relapse of UC in this patient. However, it improved the intestinal symptoms of CDI and could prevent further recurrences of CDI.

AB - Fecal microbiota transplantation (FMT) has been reported as a safe and effective therapy in patients with refractory and recurrent Clostridium difficile infection (CDI). FMT has also been reported as a promising therapy in patients with ulcerative colitis (UC). Both, CDI and UC, are believed to be caused by dysbiosis, such as altered compositions or decreased diversity of the intestinal microbiota. This report describes a patient with UC in remission with a second recurrent episode of CDI, who was treated with FMT. A single FMT performed via colonoscopy completely resolved the patient's diarrhea and eradicated C. difficile bacteriologically without any severe complications. Molecular biological analysis of the patient's fecal microbiota showed that FMT could dramatically change the altered composition of intestinal microbiota and restore its diversity. Despite the restoration of the intestinal microbiota, FMT could not prevent a relapse of UC in this patient. However, it improved the intestinal symptoms of CDI and could prevent further recurrences of CDI.

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Fecal microbiota transplantation for recurrent Clostridium difficile infection in a patient with ulcerative colitis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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