Feminizing adrenocortical carcinoma with distinct histopathological findings

Masako Hatano; Yasuhiro Takenaka; Ikuo Inoue; Keiko Homma; Tomonobu Hasegawa; Hisanobu Sasano; Takuya Awata; Shigehiro Katayama

doi:10.2169/internalmedicine.55.5912

Feminizing adrenocortical carcinoma with distinct histopathological findings

Masako Hatano, Yasuhiro Takenaka, Ikuo Inoue, Keiko Homma, Tomonobu Hasegawa, Hisanobu Sasano, Takuya Awata, Shigehiro Katayama

School of Medicine

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We herein present a 60-year-old man with adrenocortical carcinoma who had gynecomastia. An endocrinological examination revealed increased levels of serum estradiol and dehydroepiandrosterone-sulfate (DHEA-S) and reduced levels of free testosterone. Magnetic resonance imaging showed an adrenal tumor with heterogeneous intensity. Iodine-131 adosterol scintigraphy showed an increased uptake at the same site. Because feminizing adrenocortical carcinoma was suspected, right adrenalectomy was performed; the pathological diagnosis was adrenocortical carcinoma. The results of immunostaining indicated a virilizing tumor. Aromatase activity was identified on RT-PCR. As disorganized steroidogenesis is pathologically present in adrenocortical carcinoma, this diagnosis should be made with caution.

Original language	English
Pages (from-to)	3301-3307
Number of pages	7
Journal	Internal Medicine
Volume	55
Issue number	22
DOIs	https://doi.org/10.2169/internalmedicine.55.5912
Publication status	Published - 2016

Keywords

Adrenocortical carcinoma
Aromatase
Estrogen-producing tumor
Gynecomastia
Testosterone

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.55.5912

Cite this

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title = "Feminizing adrenocortical carcinoma with distinct histopathological findings",

abstract = "We herein present a 60-year-old man with adrenocortical carcinoma who had gynecomastia. An endocrinological examination revealed increased levels of serum estradiol and dehydroepiandrosterone-sulfate (DHEA-S) and reduced levels of free testosterone. Magnetic resonance imaging showed an adrenal tumor with heterogeneous intensity. Iodine-131 adosterol scintigraphy showed an increased uptake at the same site. Because feminizing adrenocortical carcinoma was suspected, right adrenalectomy was performed; the pathological diagnosis was adrenocortical carcinoma. The results of immunostaining indicated a virilizing tumor. Aromatase activity was identified on RT-PCR. As disorganized steroidogenesis is pathologically present in adrenocortical carcinoma, this diagnosis should be made with caution.",

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T1 - Feminizing adrenocortical carcinoma with distinct histopathological findings

AU - Hatano, Masako

AU - Takenaka, Yasuhiro

AU - Inoue, Ikuo

AU - Homma, Keiko

AU - Hasegawa, Tomonobu

AU - Sasano, Hisanobu

AU - Awata, Takuya

AU - Katayama, Shigehiro

PY - 2016

Y1 - 2016

N2 - We herein present a 60-year-old man with adrenocortical carcinoma who had gynecomastia. An endocrinological examination revealed increased levels of serum estradiol and dehydroepiandrosterone-sulfate (DHEA-S) and reduced levels of free testosterone. Magnetic resonance imaging showed an adrenal tumor with heterogeneous intensity. Iodine-131 adosterol scintigraphy showed an increased uptake at the same site. Because feminizing adrenocortical carcinoma was suspected, right adrenalectomy was performed; the pathological diagnosis was adrenocortical carcinoma. The results of immunostaining indicated a virilizing tumor. Aromatase activity was identified on RT-PCR. As disorganized steroidogenesis is pathologically present in adrenocortical carcinoma, this diagnosis should be made with caution.

AB - We herein present a 60-year-old man with adrenocortical carcinoma who had gynecomastia. An endocrinological examination revealed increased levels of serum estradiol and dehydroepiandrosterone-sulfate (DHEA-S) and reduced levels of free testosterone. Magnetic resonance imaging showed an adrenal tumor with heterogeneous intensity. Iodine-131 adosterol scintigraphy showed an increased uptake at the same site. Because feminizing adrenocortical carcinoma was suspected, right adrenalectomy was performed; the pathological diagnosis was adrenocortical carcinoma. The results of immunostaining indicated a virilizing tumor. Aromatase activity was identified on RT-PCR. As disorganized steroidogenesis is pathologically present in adrenocortical carcinoma, this diagnosis should be made with caution.

KW - Adrenocortical carcinoma

KW - Aromatase

KW - Estrogen-producing tumor

KW - Gynecomastia

KW - Testosterone

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Feminizing adrenocortical carcinoma with distinct histopathological findings

Abstract

Keywords

ASJC Scopus subject areas

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