Fetal goitrous hypothyroidism followed by neonatal transient hyperthyroidism: A case report

Tadashi Matsumoto, Kei Miyakoshi, Kenji Kasai, Hitoshi Ishimoto, Mamoru Tanaka, Kazushige Ikeda, Yasunori Yoshimura

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


We report a case of fetal goitrous hypothyroidism followed by neonatal transient hyperthyroidism. A fetal goiter (26 × 38 mm) was detected by ultrasound and magnetic resonance imaging at 29 weeks of gestation. Hypothyroidism was confirmed by cordocentesis, which revealed an elevated TSH (255 μIU/ml) and a low free T4 (0.4 ng/dl). The fetal goiter decreased in size after treatment with four 240-microgram intra-amniotic administrations of levothyroxine. A 2,829-gram male neonate was delivered vaginally at 37 weeks of gestation, showing an euthyroid status at birth. On day 3, free T3 was 6.9 pg/ ml and free T4 was 6.4 ng/dl, indicating hyperthyroidism. This persisted for 4 months. His thyroid functions reverted to normal at 4 months of age and have been within normal range since. Undetermined factors might be involved in the development of thyroid dysfunction in the perinatal period.

Original languageEnglish
Pages (from-to)459-462
Number of pages4
JournalFetal Diagnosis and Therapy
Issue number6
Publication statusPublished - 2003 Nov 7


  • Fetal goiter
  • Intrauterine treatment
  • Thyroid dysfunction

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Radiology Nuclear Medicine and imaging
  • Obstetrics and Gynaecology


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