Fgf/MAPK signalling is a crucial positional cue in somite boundary formation

A. Sawada, M. Shinya, Y. J. Jiang, A. Kawakami, A. Kuroiwa, H. Takeda

Research output: Contribution to journalArticlepeer-review

254 Citations (Scopus)


The temporal and spatial regulation of somitogenesis requires a molecular oscillator, the segmentation clock. Through Notch signalling, the oscillation in cells is coordinated and translated into a cyclic wave of expression of hairy-related and other genes. The wave sweeps caudorostrally through the presomitic mesoderm (PSM) and finally arrests at the future segmentation point in the anterior PSM. By experimental manipulation and analyses in zebrafish somitogenesis mutants, we have found a novel component involved in this process. We report that the level of Fgf/MAPK activation (highest in the posterior PSM) serves as a positional cue within the PSM that regulates progression of the cyclic wave and thereby governs the positions of somite boundary formation.

Original languageEnglish
Pages (from-to)4873-4880
Number of pages8
Issue number23
Publication statusPublished - 2001 Dec 27
Externally publishedYes


  • After eight
  • Fgf
  • Fused somites
  • Her1
  • Segmentation
  • Somite
  • Tailbud
  • Zebrafish

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology


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