First total synthesis of potent antitumour agent (+)-goniopypyrone

Tony K.M. Shing; Tsui Hon-Chung; Zhou Zhao-Hui

doi:10.1016/S0040-4039(00)61654-4

First total synthesis of potent antitumour agent (+)-goniopypyrone

Tony K.M. Shing, Tsui Hon-Chung, Zhou Zhao-Hui

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

The structure and absolute stereochemistry of the natural goniopypyrone is confirmed as 1 by a short and stereoselective synthesis in nine steps from d-glycero-d-gulo-heptono-γ-lactone with an overall yield of 9.7 %.

Original language	English
Pages (from-to)	691-692
Number of pages	2
Journal	Tetrahedron Letters
Volume	34
Issue number	4
DOIs	https://doi.org/10.1016/S0040-4039(00)61654-4
Publication status	Published - 1992 Jan 22

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)61654-4

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title = "First total synthesis of potent antitumour agent (+)-goniopypyrone",

abstract = "The structure and absolute stereochemistry of the natural goniopypyrone is confirmed as 1 by a short and stereoselective synthesis in nine steps from d-glycero-d-gulo-heptono-γ-lactone with an overall yield of 9.7 %.",

author = "Shing, {Tony K.M.} and Tsui Hon-Chung and Zhou Zhao-Hui",

year = "1992",

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journal = "Tetrahedron Letters",

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AU - Shing, Tony K.M.

AU - Hon-Chung, Tsui

AU - Zhao-Hui, Zhou

PY - 1992/1/22

Y1 - 1992/1/22

N2 - The structure and absolute stereochemistry of the natural goniopypyrone is confirmed as 1 by a short and stereoselective synthesis in nine steps from d-glycero-d-gulo-heptono-γ-lactone with an overall yield of 9.7 %.

AB - The structure and absolute stereochemistry of the natural goniopypyrone is confirmed as 1 by a short and stereoselective synthesis in nine steps from d-glycero-d-gulo-heptono-γ-lactone with an overall yield of 9.7 %.

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U2 - 10.1016/S0040-4039(00)61654-4

DO - 10.1016/S0040-4039(00)61654-4

M3 - Article

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SN - 0040-4039

VL - 34

SP - 691

EP - 692

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 4

ER -

First total synthesis of potent antitumour agent (+)-goniopypyrone

Abstract

ASJC Scopus subject areas

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