First total synthesis of potent antitumour agent (+)-goniopypyrone

Tony K.M. Shing, Tsui Hon-Chung, Zhou Zhao-Hui

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


The structure and absolute stereochemistry of the natural goniopypyrone is confirmed as 1 by a short and stereoselective synthesis in nine steps from d-glycero-d-gulo-heptono-γ-lactone with an overall yield of 9.7 %.

Original languageEnglish
Pages (from-to)691-692
Number of pages2
JournalTetrahedron Letters
Issue number4
Publication statusPublished - 1992 Jan 22

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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