Fish consumption and early atherosclerosis in middle-aged men

Yasuyuki Nakamura, Yoshiki Ueno, Shinji Tamaki, Takashi Kadowaki, Tomonori Okamura, Yoshikuni Kita, Naomi Miyamatsu, Akira Sekikawa, Tomoko Takamiya, Aiman El-Saed, Kim Sutton-Tyrrell, Hirotsugu Ueshima

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


To investigate the association between fish consumption and early atherosclerosis, we analyzed the relationship between fish consumption and average intima-media thickness (AveIMT) by carotid ultrasound in middle-aged Japanese men. Participants were 250 randomly selected, community-based Japanese men aged 40 to 49 years without a prior history of cardiovascular disease. AveIMT was calculated from the mean of 1-cm lengths of both the right and the left carotid arteries at 8 locations. A lifestyle survey was carried out using a self-administered questionnaire including the frequency of fish intake. There were 147 men in the fewer than 4 times per week fish consumption group and 103men in the 4 or more times per week group. The mean AveIMT was significantly higher in the low fish consumption group than in the high fish consumption group (0.623 ± 0.068 vs 0.605 ± 0.065 mm, P = .03). After adjustment for age, waist circumference, pack-years of smoking, alcohol consumption, diabetes, and lipid-lowering medications, the significant difference in the AveIMT between the 2 groups remained. However, after further adjustment for low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, and C-reactive protein in the model, the significant difference disappeared. Fish consumption may be protective against early atherosclerosis in middle-aged men, probably through its beneficial effects on inflammation.

Original languageEnglish
Pages (from-to)1060-1064
Number of pages5
JournalMetabolism: clinical and experimental
Issue number8
Publication statusPublished - 2007 Aug
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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