Five cases of childhood-onset Graves’ disease treated with either surgery or radio-iodine therapy

Kouki Tomari, Masahiro Goto, Aya Shimada, Hiroko Yagi, Yuka Nagashima, Yukihiro Hasegawa

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


There are three major therapeutic options for the treatment of Graves’ disease (GD): antithyroid drugs (ATDs), thyroidectomy, and radio-iodine (RAI) therapy. ATDs are the initial treatment option for children. However, some pediatric GD patients who are initially treated with ATDs require other type of treatments later on. We reviewed the medical records of childhood-onset GD cases retrospectively to report the clinical course of patients who received either surgery or RAI therapy subsequent to treatment with ATDs. Childhood-onset GD was successfully managed in five girls with non-ATD treatments at the age of 7–14 yr following an unfavorable outcome of initial ATD treatment. Four cases had surgery and one case was managed with RAI therapy. The reasons for switching to non-ATD treatment included poor compliance, failure to maintain remission, serious adverse events resulting from ATDs, and religious background. In conclusion, surgery and RAI therapy could be good alternative treatment options for children with GD.

Original languageEnglish
Pages (from-to)265-269
Number of pages5
Journalclinical pediatric endocrinology
Issue number4
Publication statusPublished - 2017
Externally publishedYes


  • Antithyroid drug
  • Childhood-onset
  • Graves’ disease
  • Radio-iodine
  • Thyroidectomy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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