Five-Year Outcome of LASIK for Myopia

Naoko Kato, Ikuko Toda, Yoshiko Hori-Komai, Chikako Sakai, Kazuo Tsubota

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


Purpose: To investigate the efficacy and safety of LASIK over a 5-year postoperative period. Design: Observational case series. Participants: We examined 779 eyes in 402 patients with myopia or myopic astigmatism who underwent LASIK to correct their refractive errors and received regular postoperative assessments for 5 years. Methods: Postoperative examinations were performed 1 day; 1 week; 1, 3, and 6 months; and 1, 2, 3, 4, and 5 years after LASIK surgery. Main Outcome Measures: We evaluated changes in uncorrected visual acuity (UCVA) (logarithm of the minimum angle of resolution [logMAR]), manifest refraction, best-corrected visual acuity (BCVA) (logMAR), intraocular pressure, corneal thickness, corneal endothelial cell counts, and complications. Results: Preoperative UCVA of 1.27 improved to -0.03 at 1 day after surgery and -0.08 at 1 month and revealed minimal but significant decreases thereafter. Postoperative manifest refraction was also improved by surgery, showing minimal but significant regression after 1 year. Final BCVA loss was seen in 10 eyes of 7 patients; in 7 cases, there were obvious reasons such as the progression of cataracts in 3 eyes, epithelial disintegrity due to dry eye in 2 eyes, irregular astigmatism due to flap striae in 1 eye, and age-related macular dystrophy in 1 eye. Intraocular pressure and corneal thickness decreased by 4.0 mmHg and 76.9 μm, respectively, due to surgery, but remained stable throughout the follow-up period. Corneal endothelial cell counts (2689.0±232.9 cells/mm2 before surgery) showed a statistically significant decrease at 5 years after surgery (2658.0±183.1 cells/mm2; 1.2% loss for 5 years), likely within the range due to physiological age-related loss. No serious, vision-threatening, irreversible complication such as keratectasia or progressive endothelial cell loss was observed. Conclusion: LASIK surgery is an effective and safe procedure for correcting myopia/myopic astigmatism as long as inclusion and exclusion criteria are strictly respected. However, minimal regression occurred during the 5-year investigative period.

Original languageEnglish
Pages (from-to)839-844.e2
Issue number5
Publication statusPublished - 2008 May
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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