FK506-associated limbic injury following umbilical cord blood transplantation

Y. Yoshida; H. Shimada; Takehiko Mori; H. Yoshihara; M. Takeoka; T. Takahashi

doi:10.1038/sj.bmt.1704168

FK506-associated limbic injury following umbilical cord blood transplantation

Y. Yoshida, H. Shimada, Takehiko Mori, H. Yoshihara, M. Takeoka, T. Takahashi

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A 5-year-old girl with Ph-positive chronic myelogenous leukemia, who underwent umbilical cord blood transplantation, developed two episodes of electrical status epilepticus while receiving tacrolimus (FK506) then cyclosporin A (CsA), as treatment against graft-versus-host disease. MRI including diffusion weighted MR imaging of the brain revealed abnormalities in the hippocampus and posterior white matter following FK506 and CsA treatment, respectively. While posterior white matter injury has been described with both FK506 and CsA, no previous report describes hippocampal injury from either drug. The MRI changes in the hippocampus in our case suggest possible increased susceptibility to hippocampal injury with FK506.

Original language	English
Pages (from-to)	523-525
Number of pages	3
Journal	Bone Marrow Transplantation
Volume	32
Issue number	5
DOIs	https://doi.org/10.1038/sj.bmt.1704168
Publication status	Published - 2003 Sept

Keywords

Cyclosporin A
DWI
FK506
Immunophilin
Limbic injury

ASJC Scopus subject areas

Hematology
Transplantation

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10.1038/sj.bmt.1704168

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abstract = "A 5-year-old girl with Ph-positive chronic myelogenous leukemia, who underwent umbilical cord blood transplantation, developed two episodes of electrical status epilepticus while receiving tacrolimus (FK506) then cyclosporin A (CsA), as treatment against graft-versus-host disease. MRI including diffusion weighted MR imaging of the brain revealed abnormalities in the hippocampus and posterior white matter following FK506 and CsA treatment, respectively. While posterior white matter injury has been described with both FK506 and CsA, no previous report describes hippocampal injury from either drug. The MRI changes in the hippocampus in our case suggest possible increased susceptibility to hippocampal injury with FK506.",

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AU - Yoshida, Y.

AU - Shimada, H.

AU - Mori, Takehiko

AU - Yoshihara, H.

AU - Takeoka, M.

AU - Takahashi, T.

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AB - A 5-year-old girl with Ph-positive chronic myelogenous leukemia, who underwent umbilical cord blood transplantation, developed two episodes of electrical status epilepticus while receiving tacrolimus (FK506) then cyclosporin A (CsA), as treatment against graft-versus-host disease. MRI including diffusion weighted MR imaging of the brain revealed abnormalities in the hippocampus and posterior white matter following FK506 and CsA treatment, respectively. While posterior white matter injury has been described with both FK506 and CsA, no previous report describes hippocampal injury from either drug. The MRI changes in the hippocampus in our case suggest possible increased susceptibility to hippocampal injury with FK506.

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KW - FK506

KW - Immunophilin

KW - Limbic injury

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FK506-associated limbic injury following umbilical cord blood transplantation

Abstract

Keywords

ASJC Scopus subject areas

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