Flecainide improves cardiac synchronization in an early infant with Wolff–Parkinson–White syndrome with left ventricular dyssynchrony

Recently, cases of pharmacological resynchronization for Wolff–Parkinson–White syndrome (WPWS) in children with left ventricular dyssynchrony (LVD) were reported, but an appropriate pharmacological therapy has not yet been established. A 3-month-old, previously healthy female patient was referred to our hospital due to supraventricular tachycardia (SVT). After resolution of the SVT, 12-lead electrocardiography (ECG) showed ventricular pre-excitation. Transthoracic echocardiography showed LVD with no findings of congenital heart disease or cardiomyopathy. To prevent SVT recurrence, oral propranolol administration was started, but the SVT recurred one month later. To prevent further recurrences, oral flecainide administration was started, as the patient's body weight was insufficient for catheter ablation to be performed safely. When the flecainide dosage was increased to 50 mg/m²/day, the pre-excitation resolved, and the LVD improved. Holter ECG showed that the resolution of pre-excitation depended on the serum concentration of flecainide. There are only few reports on pharmacological resynchronization in WPWS patients with LVD (LVD-WPWS). The present report is the first to examine the efficacy of flecainide in patients with recurrent SVT. Flecainide may be a safe and effective alternative resynchronization therapy for LVD-WPWS patients, especially for children in whom catheter ablation cannot be performed safely due to insufficient body weight. <Learning objective: While cases of pharmacological resynchronization for Wolff–Parkinson–White syndrome (WPWS) in children with left ventricular dyssynchrony (LVD) have been reported, an appropriate pharmacological therapy has yet to be established. Flecainide may be a safe and effective alternative resynchronization therapy for WPWS with LVD, especially for children in whom catheter ablation cannot be performed safely due to insufficient body weight.>