@article{5d3a7e1c2dc0483c998bf42b534811d4,
title = "Flow cytometric analysis as an additional predictive tool of treatment response in children with chronic-phase chronic myeloid leukemia treated with imatinib",
abstract = "Bone marrow samples of newly diagnosed children with chronic-phase chronic myeloid leukemia (CML) were obtained at diagnosis and after imatinib initiation and stained with anti-human CD34, CD38, CD123, CD45RA, cMpl, and lineage antibodies. Flow cytometric analysis revealed that granulocyte macrophage progenitor predominance in CML progenitors at diagnosis and elevated cMpl expression in bone marrow progenitors at 3 months may predict poor outcome in children with chronic-phase CML treated with imatinib. We recommend flow cytometric analysis of bone marrow in the early phase of treatment, as it is a convenient tool that may predict treatment response and guide CML management.",
keywords = "cMpl, chronic myeloid leukemia, flow cytometry",
author = "Haruko Shima and Nobutaka Kiyokawa and Masashi Miharu and Akihiko Tanizawa and Hidemitsu Kurosawa and Akihiro Watanabe and Masaki Ito and Chikako Tono and Yuki Yuza and Hideki Muramatsu and Noriko Hotta and Masahiko Okada and Kazuko Hamamoto and Ryosuke Kajiwara and Saito, {Akiko M.} and Keizo Horibe and Shuki Mizutani and Souichi Adachi and Eiichi Ishii and Hiroyuki Shimada",
note = "Funding Information: This work was supported in part by a MEXT Grant-in-Aid for Scientific Research (C), the Practical Research for Innovative Cancer Control from Japan Agency for Medical Research and development, AMED, and by grants for Clinical Cancer Research from the Ministry of Health, Labour and Welfare of Japan; H20-GanRinsho-Ippan-017, H23-GanRinsho-Ippan-014. HS, AT, and HS designed experiments, analyzed data, and wrote the paper, HK, AW, MI, CT, YY, HM, NH, MO, and KH collected samples and clinical data, NK and MM performed flow cytometric analyses, RK provided samples and clinical data, AMS, KH, SM, SA, and EI supervised the study. All authors read and approved the manuscript. The authors declare that there is no conflict of interest. Publisher Copyright: {\textcopyright} 2017 Wiley Periodicals, Inc.",
year = "2017",
month = sep,
doi = "10.1002/pbc.26478",
language = "English",
volume = "64",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "9",
}