Abstract
DnaA protein is an initiator for chromosomal DNA replication in E. coli. We have examined the function of the protein to answer the following four questions; How DnaA protein is inactivated after DNA replication for the suppression of re-initiation? How DnaA protein is activated for the initiation of DNA replication? Does DnaA protein have functions other than that for DNA replication? Is DnaA protein is a good target for new antibiotics? In this review, I summarize our recent studies for these questions.
| Original language | English |
|---|---|
| Pages (from-to) | 257-271 |
| Number of pages | 15 |
| Journal | Yakugaku Zasshi |
| Volume | 118 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 1998 Jul |
Keywords
- ATPase
- DNA replication
- DnaA protein
- Gene expression
- Inhibitor
- Phospholipid
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science