Functional dynamics of proteins revealed by solution NMR

Masanori Osawa, Koh Takeuchi, Takumi Ueda, Noritaka Nishida, Ichio Shimada

Research output: Contribution to journalReview articlepeer-review

32 Citations (Scopus)


Solution NMR spectroscopy can analyze the dynamics of proteins on a wide range of timescales, from picoseconds to even days, in a site-specific manner, and thus its results are complementary to the detailed but largely static structural information obtained by X-ray crystallography. We review recent progresses in a variety of NMR techniques, including relaxation dispersion and paramagnetic relaxation enhancement (PRE), that permit the observation of the low-populated states, which had been 'invisible' with other techniques. In addition, we review how NMR spectroscopy can be used to elucidate functionally relevant protein dynamics.

Original languageEnglish
Pages (from-to)660-669
Number of pages10
JournalCurrent Opinion in Structural Biology
Issue number5
Publication statusPublished - 2012 Oct
Externally publishedYes

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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