Functional imaging system for simultaneous measuremen t of blood volume and flow

Yohei Watanabe, Hitoshi Fujii, Eiji Okada

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Optical imaging derived from intrinsic signals such as blood volume and flow has enabled us to characterize the area of brain activation. Multi-spectral imaging of the change in cortical reectance allows the determination of the change in the oxy-hemoglobin concentration independent of the deoxy-haemoglobin concentration. The changes in blood volume and oxygenation are closely related to the cerebral blood flow, and hence the simultaneous measurement of blood volume and flow in the cortical tissue must be beneficial for investigation of functional brain activation. Laser speckle flflowgraphy has also been developed to visualize the blood flow in tissue and has been applied to measure the blood flow in tissue. In this study, a functional imaging systemhas been designed and assembled for the simultaneous measurement of the change in blood volume and flow in tissue. The optical systems of multi-spectral imaging and laser speckle flowgraphy are attached to the photo ports of the beam-splitter attachment of a stereo-microscope. The data of the multi-spectral image and speckle pattern of phantoms and finger are obtained for the initial experiments with the proposed system.

Original languageEnglish
Title of host publicationEuropean Conference on Biomedical Optics, ECBO 2003
PublisherOptica Publishing Group (formerly OSA)
Number of pages8
ISBN (Electronic)0819450111
Publication statusPublished - 2003
EventEuropean Conference on Biomedical Optics, ECBO 2003 - Munich, Germany
Duration: 2003 Jun 22 → …

Publication series

NameOptics InfoBase Conference Papers
ISSN (Electronic)2162-2701


ConferenceEuropean Conference on Biomedical Optics, ECBO 2003
Period03/6/22 → …


  • Functional imaging
  • blood flow
  • blood volume
  • laser speckle flowgraphy
  • multi-spectral imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials


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