Functionalization of hollow nanoparticles fabricated by the layer-by-layer deposition

Tomonori Toyoda, Keiji Fujimoto

Research output: Contribution to conferencePaperpeer-review


We prepared hollow particles in nano size using a layer-by-layer deposition. Liposomes were used as a template for the layer-by-layer deposition. At first, negatively charged liposomes were prepared from dilauroyl phosphatidic acid (DLPA) and dimyristoyl phosphatidylcholine (DMPC). Poly-L-lysine (PLys) and poly-L-aspartic acid (PAsp) were used as adsorbates. When the alternative adsorption of PLys and PAsp on the liposomes was repeated for thickening the capsule layer, their ζ-potentials changed between positive and negative charges at each deposition. To investigate the release from liposomes and liposome-polypeptide complex, 1-hydroxypyrene-3,6,8-trisulfonic acid (HPTS) was incorporated. From the leakage experiment in a buffered solution, we found that the adsorption of polymers was related to the release from hollow particles, and the leakage was completely inhibited by the deposition above 400ppm of PLys.

Original languageEnglish
Number of pages1
Publication statusPublished - 2005 Dec 1
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: 2005 May 252005 May 27


Other54th SPSJ Annual Meeting 2005


  • Hollow particle
  • Layer-by-Layer
  • Nanoparticle

ASJC Scopus subject areas

  • General Engineering


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