Functions and regulation of lipocalin-2 in gut-origin sepsis: A narrative review

Fanglin Lu, Kei Inoue, Jungo Kato, Shizuka Minamishima, Hiroshi Morisaki

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)


Lipocalin-2 (Lcn2), an innate immune protein, has come to be recognized for its roles in iron homeostasis, infection, and inflammation. In this narrative review, we provide a comprehensive description based on currently available evidence of the clinical implications of Lcn2 and its therapeutic potency in gut-origin sepsis. Lcn2 appears to mitigate gut barrier injury via maintaining homeostasis of the microbiota and exerting antioxidant strategy, as well as by deactivating macrophages and inducing immune cell apoptosis to terminate systemic hyper-inflammation. We propose that development of a therapeutic strategy targeting lipocalin-2 could be highly promising in the management of gut-origin sepsis.

Original languageEnglish
Article number269
JournalCritical Care
Issue number1
Publication statusPublished - 2019 Aug 2


  • Gastrointestinal microbiome
  • Inflammation
  • Lipocalin-2
  • Macrophages
  • Neutrophils
  • Sepsis

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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