Fundamental and clinical studies of cefotiam in the field of pediatrics

Hironobu Akita, Yukio Iwasaki, Satoshi Iwata, Takafumi Kanemitsu, Haruki Hattori, Keiji Jozaki, Masahiro Hotta, Naoya Yamashita, Seiichiro Nanri, Yoshibumi Kojima, Noriyoshi Hara, Keisuke Sunagawa, Tadao Oikawa, Takashi Iwata, Mitsuru Osano, Yasuo Ichihashi

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


The fundamental and clinical studies on cefotiam (CTM) were performed in the field of pediatrics, and the following results were obtained: 1. The peak MICs of CTM against Gram negative rods such as E. coli, Klebsiella, Salmonella, Proteus were 1.56mcg/ml. The MIC distribution against S. aureus was almost equal to the conventional cephalosporin antibiotics. The MICs against P. seudomonas and Serratia were over 400mcg/ml. 2. The mean serum levels of CTM after bolus intravenous injection of 25mg/kg were 59.9mg/ml after 15 min., 30.0mcg/ml after 30min., 15.6mcg/ml after 1 hour. 3. Administration of CTM to 6 pediatric patients produced the clinical responses which were good in all 6 cases and the bacterial effects of eradication in 3 cases and superinfection in the 2 cases in the 5 cases from whom the organism were isolated. No side effect was observed. From the above results, it is considered that a bolus injection of CTM 25 mg/kg t. i. d. to q. i. d. is a safe and useful treatment for pediatric cases.

Original languageEnglish
Pages (from-to)723-728
Number of pages6
Journalthe japanese journal of antibiotics
Issue number5
Publication statusPublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases


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