Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation

Hiroshi Kamiyama, Takeo Usui, Masakazu Uramoto, Hiroshi Takagi, Mitsuru Shoji, Yujiro Hayashi, Hideaki Kakeya, Hiroyuki Osada

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Epoxyquinol B (EPQB) is a fungal metabolite, containing two α,/β-epoxy ketones. We previously showed that EPQB inhibited the signal transduction involved in angiogenesis through the binding to cysteine residues of receptor kinases. However, the inhibitory mechanism was undefined. In this report, we found that one EPQB molecule is covalently bound to two X-cysteine molecules through two epoxide residues on EPQB. Furthermore, EPQB crosslinked binding proteins through the cysteine residues. These results suggest that EPQB inhibits receptor kinases by crosslinking with other protein or by intramolecular crosslinking.

Original languageEnglish
Pages (from-to)94-97
Number of pages4
JournalJournal of Antibiotics
Issue number2
Publication statusPublished - 2008 Feb
Externally publishedYes


  • Crosslink
  • Cysteine
  • Epoxide
  • Epoxyquinoid
  • Epoxyquinol B
  • Fungal metabolite

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


Dive into the research topics of 'Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation'. Together they form a unique fingerprint.

Cite this