Further characterization of foliar flavonoids in Crossostephium chinense and their geographic variation

Ayumi Uehara, Junichi Kitajima, Goro Kokubugata, Tsukasa Iwashina

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Foliar flavonoids of Crossostephium chinense in Japan and Taiwan were isolated and further characterized. Eighteen flavonoid aglycones, luteolin, apigenin, hispidulin, chrysoeriol, 5,7,4′-trihydroxy-6,3′,5′- trimethoxyflavone, jaceosidin, cilsimaritin, quercetin 3-methyl ether, axillarin, chrysosplenol-D, cirsiliol, apometzgerin, 5,7,3′-trihydroxy-6, 4′,5′-trimethoxyflavone, luteolin 3′,4′-dimethyl ether, cirsilineol, eupatilin, nepetin and 5,7,3′,4′-tetrahydroxy-6, 5′-dimethoxyflavone, were identified by UV, 1H and 13C NMR spectroscopic, LC-MS and HPLC comparisons with authentic samples. The compounds existed on the leaf surface. Four flavonoid glycosides, quercetin 3,7-di-O-glucoside, quercetin 3-O-rutinoside, luteolin 7-O-glucoside and apigenin 7-O-rutinoside, were also isolated as the intracellular flavonoids. It was shown by HPLC survey that variation of the species' flavonoids occurs among the collection sites.

Original languageEnglish
Pages (from-to)163-164
Number of pages2
JournalNatural product communications
Issue number2
Publication statusPublished - 2014 Feb
Externally publishedYes


  • Aglycone
  • Asteraceae
  • Crossostephium chinense
  • Distribution pattern
  • Flavone
  • Flavonol

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine


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