G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke

Hidenori Hattori; Akira Sonoda; Hideki Sato; Daisuke Ito; Norio Tanahashi; Mitsuru Murata; Ikuo Saito; Kiyoaki Watanabe; Norihiro Suzuki

doi:10.1016/j.brainres.2006.08.091

G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke

Hidenori Hattori, Akira Sonoda, Hideki Sato, Daisuke Ito, Norio Tanahashi, Mitsuru Murata, Ikuo Saito, Kiyoaki Watanabe, Norihiro Suzuki

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

The human lectin-like oxidized low-density lipoprotein receptor 1 (OLR1/LOX-1) is the major endothelial scavenger receptor against oxidized low-density lipoprotein (Ox-LDL), which has been implicated in the pathogenesis of atherosclerosis. We investigated the G501C mutation in the OLR1 gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 274 age- and sex-matched healthy controls using single nucleotide primer extension analysis (SNuPe). There was no significant difference in the polymorphism between patients with ischemic CVD and controls (GC + CC versus GG, p = 0.48). The C allele was not significantly different between the patients and controls (C versus G, p = 0.91). Our results show that the OLR1 gene polymorphism has little effect on an increased risk for ischemic CVD in the Japanese population.

Original language	English
Pages (from-to)	246-249
Number of pages	4
Journal	Brain Research
Volume	1121
Issue number	1
DOIs	https://doi.org/10.1016/j.brainres.2006.08.091
Publication status	Published - 2006 Nov 22
Externally published	Yes

Keywords

Atherosclerosis
Ischemic stroke
Oxidized LDL
Oxidized low-density lipoprotein receptor 1
Polymorphism
Single nucleotide primer extension

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.brainres.2006.08.091

Cite this

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title = "G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke",

abstract = "The human lectin-like oxidized low-density lipoprotein receptor 1 (OLR1/LOX-1) is the major endothelial scavenger receptor against oxidized low-density lipoprotein (Ox-LDL), which has been implicated in the pathogenesis of atherosclerosis. We investigated the G501C mutation in the OLR1 gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 274 age- and sex-matched healthy controls using single nucleotide primer extension analysis (SNuPe). There was no significant difference in the polymorphism between patients with ischemic CVD and controls (GC + CC versus GG, p = 0.48). The C allele was not significantly different between the patients and controls (C versus G, p = 0.91). Our results show that the OLR1 gene polymorphism has little effect on an increased risk for ischemic CVD in the Japanese population.",

keywords = "Atherosclerosis, Ischemic stroke, Oxidized LDL, Oxidized low-density lipoprotein receptor 1, Polymorphism, Single nucleotide primer extension",

author = "Hidenori Hattori and Akira Sonoda and Hideki Sato and Daisuke Ito and Norio Tanahashi and Mitsuru Murata and Ikuo Saito and Kiyoaki Watanabe and Norihiro Suzuki",

note = "Funding Information: This work was supported by a grant-in-aid for scientific research no. H13-genome-006 from the Ministry of Health, Labor and Welfare of Japan.",

year = "2006",

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doi = "10.1016/j.brainres.2006.08.091",

language = "English",

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T1 - G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke

AU - Hattori, Hidenori

AU - Sonoda, Akira

AU - Sato, Hideki

AU - Ito, Daisuke

AU - Tanahashi, Norio

AU - Murata, Mitsuru

AU - Saito, Ikuo

AU - Watanabe, Kiyoaki

AU - Suzuki, Norihiro

N1 - Funding Information: This work was supported by a grant-in-aid for scientific research no. H13-genome-006 from the Ministry of Health, Labor and Welfare of Japan.

PY - 2006/11/22

Y1 - 2006/11/22

N2 - The human lectin-like oxidized low-density lipoprotein receptor 1 (OLR1/LOX-1) is the major endothelial scavenger receptor against oxidized low-density lipoprotein (Ox-LDL), which has been implicated in the pathogenesis of atherosclerosis. We investigated the G501C mutation in the OLR1 gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 274 age- and sex-matched healthy controls using single nucleotide primer extension analysis (SNuPe). There was no significant difference in the polymorphism between patients with ischemic CVD and controls (GC + CC versus GG, p = 0.48). The C allele was not significantly different between the patients and controls (C versus G, p = 0.91). Our results show that the OLR1 gene polymorphism has little effect on an increased risk for ischemic CVD in the Japanese population.

AB - The human lectin-like oxidized low-density lipoprotein receptor 1 (OLR1/LOX-1) is the major endothelial scavenger receptor against oxidized low-density lipoprotein (Ox-LDL), which has been implicated in the pathogenesis of atherosclerosis. We investigated the G501C mutation in the OLR1 gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 274 age- and sex-matched healthy controls using single nucleotide primer extension analysis (SNuPe). There was no significant difference in the polymorphism between patients with ischemic CVD and controls (GC + CC versus GG, p = 0.48). The C allele was not significantly different between the patients and controls (C versus G, p = 0.91). Our results show that the OLR1 gene polymorphism has little effect on an increased risk for ischemic CVD in the Japanese population.

KW - Atherosclerosis

KW - Ischemic stroke

KW - Oxidized LDL

KW - Oxidized low-density lipoprotein receptor 1

KW - Polymorphism

KW - Single nucleotide primer extension

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G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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